Vac_63_2024_Laboratory Technician_Leukemia And Immuno-Oncology

hace 2 semanas


Badalona, España Institut Josep Carreras (Ijc) A tiempo completo

Your MissionThe Josep Carreras Leukaemia Research Institute (IJC) is a non-profit research institute based in Barcelona dedicated to advancing the understanding of leukemia and related disorders, in collaboration with the University of Barcelona and the Autonomous University of Barcelona.The IJC has laboratories in 5 clinical campuses:Hospital ClínicHospital de Sant PauHospital Germans Trias PujolHospital del MarHospital Josep Trueta GironaIJC serves as a collaborative center for basic researchers and physicians to work together on fundamental clinical and biological aspects of leukemia.
The IJC offers an excellent work environment based on a multidisciplinary fusion of state-of-the-art ideas and facilities.Research DescriptionSHP2 inhibition has emerged as a promising therapeutic strategy, leading to the development of allosteric SHP2 inhibitors that have shown encouraging results in ongoing clinical trials.
However, a significant drawback of these molecules is their inability to inhibit SHP2 mutant forms, such as those found in hematologic malignancies and, less frequently, in some solid tumors.In this context, our lab has identified six novel compounds that exhibit efficient inhibitory effects on both wild type and mutant SHP2.
The main goal of this project is to conduct a comprehensive preclinical evaluation of the therapeutic potential of these new SHP2 inhibitors by studying their spectrum of action, physicochemical properties, pharmacokinetics, and therapeutic effects on hematologic and solid tumors.Main ResponsibilitiesThe candidate will perform tasks for the development of experimental therapeutics research.
These tasks will include:Implementation of experimental methods in molecular biology and biochemistryExecution of in vitro assays using both established cell lines and primary cellsUse of specialized analytical systems such as flow cytometryDesign and execution of in vivo mouse experimentsHandling laboratory management dutiesYour ProfileMust have:At least three years of experience as a lab technician performing molecular biology and biochemistry techniques, and laboratory management dutiesExperience in the use of flow cytometryFELASA accreditation for animal experimentation and at least three years of experience working with mice as experimental models (mandatory)Fluent in spoken EnglishOther requirements:Ability to work collaboratively with others on research projectsPrevious experience in leukemia research will be positively evaluatedWhy Us?Join a young, collaborative, and international work environment with cutting-edge technologies and interdisciplinary teams of scientists, including experts in medicine, immunology, genomics, and bioinformatics.
Experience an exciting and innovative research project in the stimulating environment of the Barcelona metropolitan area.DeadlinePlease submit your application by August 21st, 2024.About UsWhat makes us different?The mission of the Josep Carreras Institute is to conduct research and drive innovation in the epidemiological, preventive, clinical, translational, and basic aspects of cancer, with a special emphasis on leukemia and other hematologic malignancies, with the final aim of finding a cure for these diseases.The IJC's vision is to be a world-class reference and excellent research multicampus that contributes to the improvement of results and the cure of patients affected by leukemia and other malignant hemopathies, through innovation, sustainability, social responsibility, talent, and professional experience.HR ExcellenceIn 2019, IJC was honored with the "Human Resources Excellence in Research Award" by the European Commission, recognizing the alignment of our human resources policies with the European Charter for Researchers and Code of Conduct for the Recruitment of Researchers.The IJC is an equal opportunity employer.
We evaluate qualified applicants without regard to race, color, religion, sex, national origin, disability, or other legally protected characteristics.#J-18808-Ljbffr


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    hace 6 días


    Badalona, Barcelona, España Institut Josep Carreras (Ijc) A tiempo completo

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  • Laboratory Technician

    hace 5 días


    Badalona, Barcelona, España Institut Josep Carreras (Ijc) A tiempo completo

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