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PhD Researcher in Immunology
hace 3 meses
PREDOCTORAL RESEARCH POSITION
The IGTP is seeking to welcome a predoctoral researcher to join the Innate Immunity Group.
Recent advancements in immune checkpoint inhibitors have led to significant improvements in the treatment of advanced cancers. Nevertheless, a considerable number of patients either do not respond to these therapies or eventually develop resistance. The combination of immunotherapies targeting various immunosuppressive pathways may enhance therapeutic effectiveness or overcome resistance.
Tumor-associated macrophages (TAMs) are influenced by the tumor microenvironment, adopting a phenotype that promotes tumor growth. These cells are the primary immune component within tumors, making them a highly attractive target for immuno-oncology interventions.
Our objective is to further develop a pioneering immunotherapy aimed at TAMs. We have identified a crucial checkpoint in the formation of tolerogenic macrophages, which holds great promise for numerous solid tumors. Our research encompasses TAM biology, integrating clinical observations, fundamental research, and mathematical modeling to support the creation of a new monoclonal antibody-based therapy that can reprogram TAMs from a tolerogenic to a pro-inflammatory state. This research will be complemented by preclinical studies in animal models, demonstrating that our therapy modifies the intratumoral microenvironment, alters the immune cell profile (including TAM phenotype), reduces blood vessel density, and enhances inflammation, ultimately leading to decreased tumor progression.
The focus of this PhD thesis is to deepen our understanding of TAM biology, aid in the development of our immunotherapy by clarifying its mechanisms and potential applications, and ultimately contribute to the creation of a novel cancer treatment. A unique aspect of this role is the opportunity for the PhD candidate to collaborate closely with TAM Therapeutics, our spin-off dedicated to the regulatory, clinical, and commercial advancement of this research. This collaborative relationship will provide the candidate with invaluable insights into the translational dimensions of scientific research, bridging the gap between academia and industry. The candidate will gain expertise in cutting-edge research while acquiring essential knowledge and skills for the practical application of findings in both preclinical and clinical contexts, significantly enhancing their academic and professional journey.
We are looking for a highly motivated individual eager to advance their scientific career in a supportive and dynamic environment within the realm of translational cancer immunology research.
QUALIFICATIONS AND EXPERIENCE:
Required:
- Candidates must possess a BSc and MSc degree in biological or biomedical sciences at the time of recruitment, enabling enrollment in an official PhD program.
- A BSc qualification with a minimum score of 8/10.
- Proficiency in English, both spoken and written.
- Willingness to conduct preclinical studies in animal models under appropriate supervision.
Valued:
- Background knowledge in immunology, oncology, and/or cancer immunotherapy.
- Contributions to published research as a co-author.
- Practical research experience in national or international laboratories.
- Participation in national or international conferences.
- Proven ability to communicate complex scientific concepts clearly and work collaboratively within a research team.
- Strong organizational skills and ability to meet deadlines.
- A proactive and self-motivated approach.
MAIN RESPONSIBILITIES:
Experimental Work:
- Conduct in vitro functional and phenotypic analyses of macrophages and immune cells in the context of cancer using primary cells and cell lines.
- Participate in the execution of preclinical cancer models and sample analysis.
- Investigate biomarker expression in human samples using techniques such as immunohistochemistry, immunofluorescence, or RT-PCR-Sequencing.
Additional Responsibilities:
- Maintain a thorough understanding of the research field through literature review.
- Analyze and interpret experimental data, contributing to manuscript preparation.
- Actively engage in laboratory meetings, IGTP seminars, and national/international conferences.
WHAT WE OFFER:
- Full-time contract.
- Competitive gross annual remuneration based on experience and skills, distributed in 12 payments.
- Flexible payment options.
- Generous holiday allowance.
- Training opportunities provided by the organization.
- A chance to be part of a distinguished multidisciplinary research center.
- A stimulating scientific environment that fosters professional development and supports research goals.
FOR MORE INFORMATION:
HOW TO APPLY:
Interested candidates should submit a cover letter detailing their interest in the position, along with their CV and contact information for 2-3 references.
Applications will be evaluated based on the principles and objectives of the selection process, including a review of the curriculum vitae and a personal interview for shortlisted candidates.
