PhD offer within the Myelodysplastic Neoplasia group, CIMA Universidad de Navarra, for the 26/27 Academic Year
hace 2 semanas
The Myelodysplastic Neoplasia Group, led by Dr. Irene Gañán is looking for a candidate to carry out the doctoral thesis for the 26/27 academic year.
Myelodysplastic syndromes (MDS) are genetically heterogeneous hematologic malignancies associated with aging and with the risk of developing acute myeloid leukemia. MDS arise with the expansion of
hematopoietic stem cells
with genetic and/or cytogenetic alterations in the bone marrow. Proliferation of aberrant cell clones induces ineffective differentiation, which in turn results in peripheral blood cytopenias.
MDS patients have low survival rates due to their limited therapeutic options and the fact that these, for the most part, are not curative. Among the reasons for the historical lack of effective therapies against MDS are their great genetic heterogeneity and an
incomplete understanding of the mechanisms that facilitate the survival and expansion
of MDS stem cells.
Our group, integrated in the
Cancer Center Clínica Universidad de Navarra
, investigates the cellular and molecular mechanisms that lead to the development of MDS, therapy failure and disease progression. To do so, we take a
comprehensive approach
, allowing us to put the mechanisms intrinsic to hematopoietic stem cells in context with the extrinsic mechanisms that enable their survival and expansion, using multidisciplinary methods and state-of-the-art techniques.
Impact of our research
Currently, the only curative therapy for MDS is
bone marrow stem cell transplantation
, for which only a
small percentage of patients are candidates
. Existing
therapeutic alternatives
for the remaining patients
can correct the symptomatology in about half of them
, but have a
short-lasting effect
and the appearance of resistance is associated with a very rapid progression of the disease. Characterization of the global spectrum of hematopoietic stem cell alterations and other cell lineages that lead to the onset, maintenance and progression of MDS will allow the identification of targets for the development of new therapies that can eliminate aberrant cells and
prevent or slow disease progression
.
Last Publications
Requirements
The Myelodysplastic Neoplasia Group, led by Dr. Irene Gañán, is seeking for a creative, ambitious and highly motivated candidate to joint as a PhD student. The candidate will join a highly collaborative environment with the opportunity to apply cutting-edge genomic technologies on the field of Hematology Oncology. The work will be in permanent collaboration with an interactive international team of basic and translational researchers and in collaboration with the Computational Biology Program at CIMA.
The candidate must have a University degree in Sciences (Biology, Biochemistry, Pharmacy, Biotechnology…) with at least 8/10 marks (For those studies outside of Spain, we would need the equivalent marks through ). Moreover, the candidate must be currently enrolled in a Master's program that grants access to doctoral studies, with a planned completion date of September/October 2026, or already completed in 2025.
Knowledge on Computational Biology / Bioinformatics will be valued
Include
CV, motivational letter and University degree marks / equivalent marks
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