Vac_55_2024_Immerge: Doctoral Candidate Position_European Molecular Biology Laboratory Heidelbe...

hace 4 semanas


Badalona, España Josep Carreras Leukaemia Research Institute (Ijc) A tiempo completo

30 jul | Josep Carreras Leukaemia Research Institute (Ijc) | Municipio de BadalonaHOST INSTITUTION: European Molecular Biology Laboratory Heidelberg (EMBL), Germany > HeidelbergDegree awarding institution: EMBL, Heidelberg, GermanySupervisor: Dr. Sinem SakaPlanned secondment(s): UKLFR to receive training on patient sample processing and learn about signaling pathways, m10-m12 (2 months); Alia Therapeutics to learn novel gene editing protocols, m18 (1 month); University of Basel to receive multi-omics analysis, m23-24 (2 months).The IMMERGE MSCA Doctoral Network (DN) is a multidisciplinary training initiative dedicated to recruiting 12 Doctoral Candidates (DCs) in the fields of Immunology, Epigenetics, Omics, Gene Editing Technologies, and Bioinformatics. The program aims to answer essential questions regarding Inborn Errors of Immunity (IEI), such as the relationship between genetic mutations and clinical phenotypic expressivity and drug response, the modulation of mutation effects by genetic background or environmental factors, and the interplay between these mutations and cell signaling pathways.The DCs will be enrolled in top-notch academic and non-academic institutions, working with experts in various fields including immunology, genetics, epigenetics, proteomics, single-cell omics, bioinformatics, and gene correction.Participating institutions represent 7 different countries, with 8 academic and 2 non-academic members from the biotech sector. The program includes a tailored training initiative with 16 Associated Partners providing additional expertise.Individual Research ProjectDoctoral Candidate 13: Understanding the impact of IEI on RNA processing and lifecycle with new methods.Rationale and Objectives: For IEIs that do not impede transcription, it is unclear if the produced RNA suffers from aberrations throughout its lifecycle. DC13 will study how IEIs affect the downstream processing and lifecycle of mutant RNAs by comparing mutant versus wildtype RNAs. Specific aims include:To develop a highly sensitive in situ proximity detection method for annotating RNAs based on their functional state.To combine this method with in situ detection of mutations and corrections in cells and tissues.To identify RNAs with IEI mutations at single molecule level in heterozygous samples from patients and assess the impact on RNA processing.The in situ mutation detection capabilities developed will enable evaluation of gene editing approaches within the spatial organization at the cell and tissue level.Expected Results:Generalizable methods and protocols for RNA lifecycle stage annotation.Integratable approaches for in situ mutation detection.Identification of the impact of IEI mutations on RNA lifecycle dynamics.#J-18808-Ljbffr



  • Badalona, España Josep Carreras Leukaemia Research Institute (Ijc) A tiempo completo

    30 jul | Josep Carreras Leukaemia Research Institute (Ijc) | Municipio de Badalona HOST INSTITUTION: European Molecular Biology Laboratory Heidelberg (EMBL), Germany > Heidelberg Degree awarding institution: EMBL, Heidelberg, Germany Supervisor: Dr. Sinem Saka Planned secondment(s): UKLFR to receive training on patient sample processing and learn about...


  • Badalona, España Institut Josep Carreras (Ijc) A tiempo completo

    .Your missionHOST INSTITUTION: European Molecular Biology Laboratory Heidelberg (EMBL), GermanyHeidelbergDegree awarding institution: EMBL, Heidelberg, GermanySupervisor: Dr. Sinem SakaPlanned secondment(s):UKLFR to receive training on patient sample processing and learn about signaling pathways, m10-m12 (2 months); Alia Therapeutics to learn novel gene...


  • Badalona, España Institut Josep Carreras (Ijc) A tiempo completo

    .Your missionHOST INSTITUTION: European Molecular Biology Laboratory Heidelberg (EMBL), GermanyHeidelbergDegree awarding institution: EMBL, Heidelberg, GermanySupervisor: Dr. Sinem SakaPlanned secondment(s):UKLFR to receive training on patient sample processing and learn about signaling pathways, m10-m12 (2 months); Alia Therapeutics to learn novel gene...

  • Laboratory Technician

    hace 6 días


    Badalona, Barcelona, España Institut Josep Carreras (Ijc) A tiempo completo

    About the RoleThe Institut Josep Carreras (IJC) is seeking a highly skilled Laboratory Technician to join our team in the Leukemia and Immuno-Oncology Research department. As a Laboratory Technician, you will play a crucial role in the development of experimental therapeutics research.Key ResponsibilitiesImplement experimental methods in molecular biology...

  • Laboratory Technician

    hace 5 días


    Badalona, Barcelona, España Institut Josep Carreras (Ijc) A tiempo completo

    About the RoleThe Institut Josep Carreras (IJC) is seeking a highly skilled Laboratory Technician to join our team in the Leukemia and Immuno-Oncology Research department. As a Laboratory Technician, you will play a crucial role in the development of experimental therapeutics research.Key ResponsibilitiesImplement experimental methods in molecular biology...


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  • Badalona, Barcelona, España Institut Josep Carreras (IJC) A tiempo completo

    Your MissionThe Institut Josep Carreras (IJC) is a prestigious non-profit research organization dedicated to enhancing the understanding of leukemia and related disorders. Collaborating with esteemed institutions, IJC operates across multiple locations, serving as a hub for both fundamental and clinical research in hematological diseases. We are currently...

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    hace 6 días


    Badalona, Barcelona, España Institut Josep Carreras (Ijc) A tiempo completo

    About the RoleThe Institut Josep Carreras (IJC) is seeking a highly skilled Laboratory Technician to join our Single Cell Unit. As a key member of our team, you will play a crucial role in supporting high-level research projects in the single-cell genomics field.Key ResponsibilitiesSupport internal and external single-cell DNA, RNA, and spatial...

  • Laboratory Technician

    hace 5 días


    Badalona, Barcelona, España Institut Josep Carreras (Ijc) A tiempo completo

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    hace 1 día


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  • Lab Assistant Trainee

    hace 24 horas


    Badalona, Barcelona, España Institut Josep Carreras (IJC) A tiempo completo

    About the RoleWe are seeking a highly motivated and skilled Lab Assistant Trainee to join our Cancer Metabolism group at the Institut Josep Carreras (IJC). The successful candidate will be responsible for establishing and maintaining cellular models relevant to our research aims, applying cell biology and molecular biology techniques to characterize these...


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  • Badalona, Barcelona, España Institut Josep Carreras (IJC) A tiempo completo

    Your RoleThe Institut Josep Carreras (IJC) is a distinguished non-profit research organization focused on enhancing the understanding of leukemia and related conditions. Collaborating with esteemed institutions, IJC operates multiple laboratories dedicated to groundbreaking research in hematological malignancies. We are currently seeking a Laboratory...


  • Badalona, Barcelona, España Institut Josep Carreras (IJC) A tiempo completo

    Position OverviewThe Josep Carreras Leukaemia Research Institute (IJC) is a leading nonprofit research organization located in the Barcelona metropolitan area, dedicated to enhancing our understanding of leukaemia and related disorders. In collaboration with the University of Barcelona and University Autònoma of Barcelona, IJC operates laboratories across...


  • Badalona, Barcelona, España Institut Josep Carreras (IJC) A tiempo completo

    Your MissionThe Institut Josep Carreras (IJC) is a distinguished non-profit research organization located in Barcelona, dedicated to enhancing the understanding of leukemia and related disorders. Collaborating closely with the University of Barcelona and the Autonomous University of Barcelona, IJC operates across five key locations, serving as a hub for both...


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    About TradebeTradebe is a global leader in the environmental sector, serving various markets, including industrial, petrochemical, pharmaceutical, oil and gas, etc.Job DescriptionTecnoambiente, a subsidiary of TRADEBE, is a multidisciplinary company specializing in geosciences-environmental studies, underwater inspections, and environmental consulting, with...


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    About TradebeTradebe is a global leader in the environmental sector, serving various markets, including industrial, petrochemical, pharmaceutical, oil and gas, etc.Job DescriptionTecnoambiente, a subsidiary of TRADEBE, is a multidisciplinary company specializing in geosciences-environmental studies, underwater inspections, and environmental consulting, with...


  • Badalona, Barcelona, España Institut Josep Carreras (IJC) A tiempo completo

    Position OverviewThe Josep Carreras Leukaemia Research Institute (IJC) is a prestigious nonprofit organization located in the Barcelona metropolitan area, committed to enhancing our knowledge of leukaemia and related disorders. Collaborating closely with the University of Barcelona and the University Autònoma of Barcelona, IJC operates across three clinical...


  • Badalona, Barcelona, España Institut Josep Carreras (IJC) A tiempo completo

    Position OverviewThe Josep Carreras Leukaemia Research Institute (IJC) is a prestigious nonprofit research organization located in the Barcelona metropolitan area, committed to enhancing our understanding of leukaemia and related disorders. In collaboration with the University of Barcelona and University Autònoma of Barcelona, IJC operates laboratories...

  • Laboratory Technician

    hace 6 días


    Badalona, Barcelona, España Institut Josep Carreras (Ijc) A tiempo completo

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