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Executive Director, Global Project Leader
hace 2 meses
.At AstraZeneca, we are committed to advancing the science of oncology to deliver life-changing medicines to patients most in need. With a combination-focused pipeline that exploits the power of six scientific platforms (Immuno-Oncology, Tumor Drivers and Resistance, DNA Damage Response, Antibody-drug Conjugates, Cell Therapy, and Epigenetics) to help address unmet clinical needs in a host of cancers, we are motivated by a dedication to the scientific discovery and collaboration that will one day help eliminate cancer as a cause of death.The Hematology Research and Development (R&D) team is accountable for all drug development activities in hematology research from first-in-man studies, all the way to late-stage trials leading to drug approval by regulatory agencies (Phase 1, 2, and 3 trials). The team strives to deliver compelling preclinical, clinical, and translational data packages providing confidence in the dosing strategy, tolerability profile, and therapeutic efficacy of our candidate drugs to support investment in late-stage clinical development, leading to drug approval.We are looking for a highly qualified candidate to lead the development and execution of the product strategy for one or more projects. This individual will be accountable for the strategic leadership and execution and act as the champion for the product candidates. The individual will develop a range of strategic and tactical options, secure governance and budget approval, secure cross-functional resources for the projects, and then take accountability for execution, monitoring, and reporting of progress/issues.Major Duties and Responsibilities:Leads product development teams responsible for novel Hematology Oncology therapies from preclinical candidate selection through proof of concept leading to Phase 3 investment decisions. The candidate will lead all regulatory submissions. Accountable for the strategy and execution of a portfolio of pre-clinical and clinical-stage therapies.Accountable for the delivery of projects according to quality, time, budgets, and resources.Build strategic and coordinated product development plans that are aligned with business objectives and are differentiated from competitor products.Accountable for the execution of the coordinated product plan to the agreed scope, timelines, and budgets.Leads and communicates the project development strategy at governance meetings, accountable for aligning with internal management and for communicating with external collaborators.Lead projects from preclinical Lead Optimization Investment Decision to clinical Proof of Concept (PoC).Responsible for all aspects of project strategy including preclinical, translational, clinical development, patient selection, regulatory, pediatric, intellectual property, CMC, and Asian development strategy.Development of the Target Product Profile, ensuring alignment with disease area strategy and late-stage development