New Immunotherapeutic Tools For The Treatment Of Cancers With Poor Prognosis

Organisation/Company Agencia Estatal Consejo Superior de Investigaciones Científicas Department Instituto de Investigaciones Biomédicas de Madrid -IIBM- Research Field Medical sciences » Cancer research Biological sciences » Biological engineering Researcher Profile First Stage Researcher (R1) Positions PhD Positions Application Deadline 22 Nov ***:00 (Europe/Madrid) Country Spain Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 7 Dec Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No
Offer Description
The project will involve the development of new immunotherapeutic tools for the treatment of cancers with poor prognosis, including new lentiviral vectors for TRUCKs with expression regulated by the tumor microenvironment. We also will study the modulation of the immune synapse to enhance the effector function and persistence of CAR T cells.
This project is funded by the Consortium in Biomedicine Program from Community of Madrid. Our consortium, the Next Generation ImmunoTherapy Madrid is a joint effort by basic and clinic groups. Therefore, both the
scientific and medical relevance of the project is particularly strong
. It integrates immunology, molecular and cellular engineering, tumor biology, advanced microscopy and clinically relevant preclinical models to address a major limitation of current CAR therapies. The objective is not simply to develop a new experimental tool, but a therapeutic candidate with potential application in patients with refractory or relapsed B-cell malignancies, including aggressive pediatric cancers with poor prognosis.
The PhD student will be
based in the host IIBM-CSIC laboratory
. This Institute provides access to state-of-the-art technologies including advanced flow cytometry, confocal and STED microscopy, in vivo imaging, animal facilities, high-field MRI. Genomic facility and more.
A major strength of the project is its
strong translational potential
. The combination of an original 4th generation CAR platform with direct access to collaborators with clinical expertise, as well as availability of clinically validated CAR components provides a clear pathway towards future clinical development.
Overall, this PhD offers the opportunity to work at the
frontier of cellular immunotherapy in a laboratory that originated and leads new CAR platforms
, while being part of a high-level scientific and clinical collaboration.
Requirements
Research Field Medical sciences » Cancer research Education Level Master Degree or equivalent
Skills/Qualifications
Strong academic record.
Previous research experience.
Background in immunology, cancer biology, molecular/cellular biology or hematology.
Experience with cell culture, flow cytometry, microscopy, molecular biology or functional cellular assays
Capacitation to work with animal models. Certification will be a plus.
Previous experience with CAR-T/CAR-NK cells, immune-cell engineering, primary human cells or preclinical cancer models will be considered an advantage.
Publications, conference presentations, research awards or previous research stays.
Strong analytical, problem-solving and teamwork skills.
Motivation for a career in translational cancer research.
Specific Requirements
Bachelor's degree or equivalent in Biology, Biochemistry, Biotechnology, Biomedicine, Medicine, Pharmacy or a related discipline.
Master's degree or equivalent qualification providing access to doctoral studies, completed or expected before the start of the position.
Eligibility for admission to the corresponding doctoral programme in Spain.
Good written and spoken English.
Demonstrated interest in biomedical research.
Research Field Biological sciences
Internal Application form(s) needed
euraxess PhD position_IIBM_CSIC_Spain.pdf
Predoctoral contract **** € (including salary and social security cost) (4 years)
The PhD student will join a
highly stimulating, collaborative and multidisciplinary research environment
, working at the interface of cancer immunology, cellular engineering and translational medicine. The project offers access to state-of-the-art technologies, leading scientific expertise and a strong network of national and international collaborators, while providing close interaction with both basic and clinical researchers. The student will benefit from an environment that encourages
scientific curiosity, independent thinking, collaboration and professional development
, with opportunities to participate in seminars, conferences, research stays and international collaborations. This setting provides an excellent foundation for developing the experimental, analytical and scientific skills required for a successful research caree