Postdoctoral Researcher

**The Institute**

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.

In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).

Please, check out our Recruitment Policy
**The role**

We are seeking an highly motivated Postdoctoral Researcher, ideally with mixed/hybrid background in Molecular Biology (wet lab) & Bioinformatics (dry lab), to join the Epitranscriptomics and RNA Dynamics group (PI: Eva Novoa), to the study of the role of RNA modifications (the “epitranscriptome”) in sperm RNAs using nanopore sequencing technologies.

Your work would be part of the project “Dissecting the role of sperm transcriptome dynamics in intergenerational inheritance through native RNA nanopore sequencing”, which has been funded by the European Research Council (ERC), in which we aim to study how different dietary intakes (e.g. high fat diet) affect the sperm RNA populations and their RNA modifications, and how these changes in sperm RNA can lead to altered metabolic profiles in the next generations.

**About the lab**

Our lab is focused on deciphering the role that RNA modifications play in a large variety of cellular contexts, including the development of novel technologies to map RNA modifications. In our lab, we are employing a combination of experimental (RNASeq, RIP-Seq polysome profiling, mouse/cell knockouts, Oxford Nanopore direct RNA sequencing) and computational techniques (NGS data analysis, algorithm development, machine learning), to unveil the secrets of three post-transcriptional regulatory layers: the epitranscriptome, RNA structure and ribosome specialization.
**Whom would we like to hire?**
**Professional experience**

You will also possess the following key skills and attributes:
**Must Have**
- You have a background in RNA biology
- You have basic programming/data analysis skills, preferably in Python or R
- You have published at least one primary research paper during your PhD
**Desirable but not required/ Nice to have**

**Wet lab**:

- You have experience in sperm RNA extraction techniques and/or sperm manipulation
- You have experience with Oxford Nanopore sequencing library preparation
- You have experience with microinjections in zygotes
- You have experience with rodents
- You have experience experience with Glucose Tolerance Tests (GTT) and/or Insulin Tolerance Tests (ITT) in mice
- You have an Animal Experimentation title that is recognized by the Catalan Government

**Dry lab**:

- You have the ability to code in R and/or Python
- You have the ability to use HPC clústers to submit jobs
- You have experience in the analysis of nanopore sequencing data
- You have experience in the analysis of illumina sequencing data

**Education and training**
- You hold a PhD degree in Molecular Biology, Biology, Biochemistry or similar field.
**Languages**
- You must be fluent in oral and written English
**Competences**
- You have excellent analytical and problem-solving skills
- You have the capacity for carrying out duties under mínimal supervision
- You have the drive and commitment to produce high quality experimental outcomes
- You have highly developed organization skills
- You have the ability to work as part of a team
- You have good academic writing skills
**The Offer - Working Conditions**
- **Contract duration**:2 years (renewable up to 5 years).
- **Estimated annual gross salary**: Salary is commensurate with qualifications and consistent with our pay scales.
- **Target start date**:1st May 2021 (flexible).

We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section.

We offer and **promote a diverse and inclusive environment **and welcomes applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity.

The **CRG is committed to reconcile a work and family life **of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.