Research Technician Position

**The Institute**

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.

In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).

Please, check out our Recruitment Policy

**The role**

**About the l**ab**

Understanding the genetic basis of cancers has been a topic of intense research, and hundreds of gene mutations have been identified that can cause carcinogenesis. However, in the past few years, increasing evidence has suggested that mutations are not the only genetic changes that lead to cancer. Indeed, perturbations of chromatin structure and of other epigenetic mechanisms can cause inappropriate gene expression and genomic instability, resulting in cellular transformation and malignant outgrowth. Our research investigation is focused on understanding the role of several protein complexes that are involved in chromatin dynamics and metabolism, which when altered could participate in the establishment and maintenance of the aberrant silencing of tumor suppressor genes during transformation.

**Whom** would we like to hire?**

**Professional experience**

**Must Have**
- You have 5 years of experience in molecular biology; gene regulation; epigenetics
- You have proven experience HiC and spatial transcriptomics
- You are fluent in English
- You have previous experience in the field of molecular and cellular biology
- You have advance knowledge of bioinformatic analysis

**Education and training**
- You hold a PhD in Biology or equivalent

**Languages**
- English fluency

**Technical skills**
- You have knowledge of molecular biology techniques (general DNA and RNA manipulation techniques including purification, cloning, mutagenesis, PCR, RT-PCR, qPCR)
- You have knowledge of chromatin Immunoprecipitation
- You have knowledge of proteomic techniques (protein extraction, subcellular fractionation,

western blot, protein-protein interaction techniques)
- You have experience with cell culture of primary and stablished cell lines

**Competences**
- Highly developed organizational skills

**The Offer** - Working Conditions**
- **Contract d**uration**: Technical and scientific activities contract linked to the project (estimated duration 2 years)
- **Estimated annual gross salary**: Salary is commensurate with qualifications and consistent with our pay scales
- **Target s**tart date**: 03/2025

We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section.

**We offer and**promote a diverse and inclusive environment** and welcomes applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity.

**The CRG is committed to reconcile a work and family life** of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.