Computational Biologist for The Inflammation

Created in 2005 by the Generalitat de Catalunya (Government of Catalonia) and the University of Barcelona, IRB Barcelona is a Severo Ochoa Centre of Excellence—a seal that was awarded in 2011.

The institute is devoted to conducting research of excellence in biomedicine and to transferring results to clinical practice, thus improving people’s quality of life, while simultaneously promoting the training of outstanding researchers, technology transfer, and public communication of science. Its 28 laboratories and seven core facilities address basic questions in biology and are orientated to diseases such as cancer, metastasis, Alzheimer’s, diabetes, and rare conditions.

IRB Barcelona is an international centre that hosts 400 members and 35 nationalities. It is located in the Barcelona Science Park. IRB Barcelona forms part of the Barcelona Institute of Science and Technology (BIST) and the “Xarxa de Centres de Recerca de Catalunya” (CERCA).

**IRB Barcelona is seeking a motivated and enthusiastic scientist to join the Inflammation, Tissue Plasticity & Cancer laboratory (led by Dr. Direna Alonso-Curbelo) as a Bioinformatician.**

**Our lab aims to understand how oncogenic mutations and environmental insults alter normal cellular identity and tissue homeostasis to drive and sustain tumorigenesis, to define **tumor-cell and microenvironmental mechanisms of cancer pathogenesis and identify specific vulnerabilities that may be therapeutically exploited**. To do so, our strategy involves a dynamic dialogue between computational efforts enabling inference of relevant biological information from NGS omics datasets (including single-cell data) and funcional perturbation approaches (using CRISPR/Cas9, RNAi, mouse models and organoid/cell culture systems) to establish causality between disease-associated traits and cancer phenotypes. Through this reciprocal interplay between profiling and function, we aim to transform the breadth of existing and new datasets into new knowledge on cancer mechanisms, early biomarkers and therapeutic opportunities.**

**Starting date: as soon as possible.**

**DUTIES**:

- ** Research activities may include**:

- Develop and/or implement data analysis workflows and visualization tools for bulk and single-cell multi-omics data (including epigenomics, transcriptomics, and eventually mass spec and multidimensional spatial data).
- Search, manage, organize, and store datasets; and develop workflows for effective computationally reproducible research.
- Integrate molecular and clinical/phenotypic data to identify predictive and prognostic features.
- Discuss results, elaborate reports, and participate and present in group meetings and scientific discussions.
- Train, oversee, and provide advice to group members on best practices regarding bioinformatics and statistical approaches.
- **Learning **opportunities & Team dynamics**:

- The bioinformatician/computational biologist will also be able to develop and/or implement computational analysis workflows with the help of scientists at the Biostatistics & Bioinformatics Core and already established pipelines.

**EXPERIENCE, KNOWLEDGE, SKILLS**:
**Must Have - Required**
- **Experience**:

- Bachelor’s or Master’s degree in Bioinformatics or other related degrees in biology or health sciences
- Understanding of omics data and biological processes.
- **Knowledge**:

- Working experience in programming languages such as Python or R.
- Knowledge and demonstrated experience in management, analysis, integration and visualization of molecular/omics data obtained from NGS technologies, including single-cell transcriptomics or epigenomics (eg RNA-seq, ATAC-seq, scRNA/ATAC-seq).
- Knowledge of statistical principles and biostatistics analysis tools.
- Be familiar with publicly available resources, datasets, and tools for functional and/or gene regulatory analyses relevant for cancer genetics (TCGA, ENCODE, FANTOM, GO, Genome viewers, Human Cell Atlas Data Portal, etc.).
- **Skills**:

- Proactive person, motivated to learn new technologies and analysis workflows.
- Ability to work independently well as a team member.
- Ability to perform multiple tasks independently.
- Time
- and deadline-management skills. Highly organized.
- Effective communication and interpersonal skills.
- **Languages**: Proficient in English (oral and written).

**Desirable**:

- ** Experience**:

- Prior experience in competitive research environments.
- Understanding of cancer biology and/or immunology.
- **Knowledge**:

- Computational analysis of spatial/imaging data.
- Computational analysis of high-content pooled genetic screens (CRISPR/shRNA).
- Practical experience with trajectory interference analysis from single-cell data.

**WORKING CONDITIONS & ENTITLEMENTS**:

- **Working conditions**: Employed in compliance with Spanish legislation and regulations under a full-time contract. Employees receive the benefits of the Spanish Social Security system covering sickne