POSTDOCTORAL POSITION IN MOLECULAR BIOLOGY
hace 4 días
Organisation/Company Institute of Neurosciences Research Field Neurosciences » Neurobiology Researcher Profile Recognised Researcher (R2) Positions Postdoc Positions Country Spain Application Deadline 30 Jan 2026 - 23:59 (Europe/Madrid) Type of Contract Temporary Job Status Full-time Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No Offer Description We are looking for Postdoctoral researchers to join the research group “Molecular Biology of Huntington’s disease” leaded by Dr. Veronica Brito at the Department of Biomedicine Institute of Neuroscience, University of Barcelona and Institut de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS). Brito’s lab’s main goal is to elucidate the molecular and cellular mechanisms by which the mutant Huntington’s disease gene drives selective neurodegeneration and to translate this knowledge into novel therapeutic strategies. Huntington’s disease (HD) is a fatal, inherited neurodegenerative disorder caused by an expanded CAG repeat in the HTT gene, leading to cognitive, motor, and psychiatric disturbances in patients. While somatic CAG-repeat expansion is recognized as an early event in HD pathogenesis, it remains to be fully understood how this DNA-level mutation gives rise to neuronal pathology. Several evidences have revealed that aberrant RNA processing and the production of HTT1a, a toxic truncated transcript, play key roles in disease progression. The postdoctoral researcher will join the team to contribute to an ongoing, cutting-edge project that builds on our recently published findings suggesting that N6- methyladenosine (m6A) marks on HTT RNA contribute to the generation of toxic HTT1a transcripts. The project aims to investigate how this RNA modification regulates the pathogenic HTT1a transcript in HD, elucidating the molecular links between m6 A deposition, DNA repair, transcriptional dynamics, and aberrant RNA processing within HTT. By defining the role of m6A RNA modifications as a novel layer of gene expression regulation—both at the disease locus and transcriptome-wide—this work seeks to uncover fundamental mechanisms of disease and lay the groundwork for innovative RNA-targeted therapeutic approaches in HD. The project integrates advanced RNA-mapping technologies (Direct RNA sequencing using Oxford Nanopore Technology) and CRISPR-based RNA editing tools to define how m6A controls HTT1a expression and to develop new strategies for precise epitranscriptomic modulation in disease models. This position focuses on experimental investigation of the molecular mechanisms underlying HTT1a expression in Huntington’s disease. The successful candidate will lead the design and execution of molecular and cellular assays, including RNA–protein interaction studies, RNA modification detection, DNA-RNA interaction and DNA repair assays as well as functional validation of bioinformatic predictions in cellular and mouse models. #J-18808-Ljbffr
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Group Leader
hace 7 días
Barcelona, España European Molecular Biology Laboratory A tiempo completoScience Faculty Barcelona, Spain EMBL Barcelona is a research unit focusing on **Tissue Biology and Disease Modelling**. _We build tissues to understand them_, either _in vitro_ or _in silico_. We go beyond the molecular and cellular scale to ask questions such as: How do thousands of cells dynamically self-organise to create tissues and organs? How do new...
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Postdoctoral Fellow
hace 1 semana
Barcelona, España European Molecular Biology Laboratory A tiempo completoResearch Barcelona, Spain The European Molecular Biology Laboratory (EMBL) is one of the highest ranked scientific research organizations in the world. The newest EMBL site is located in the Barcelona Biomedical Research Park (PRBB), one of the largest infrastructures in Southern Europe dedicated to translational research. The main focus of the EMBL...
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Lab Technician Position in Chemical Biology
hace 3 días
Barcelona, España Institute for Research in Biomedicine (IRB Barcelona) A tiempo completo**Ref. LAB/22/19** This position will be financed by the project “Directed degradation and localization of proteins: new solutions against pancreatic cancer”, financed by the Spanish Research Agency (PID2020-120110RA-I00/ AEI /10.13039/501100011033). DUTIES: Cell culture (maintenance, cellular viability assays) Functional genomics (CRISPR/Cas9...
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Barcelona, España IRB Barcelona A tiempo completoCreated in 2005 by the Generalitat de Catalunya (Government of Catalonia) and the University of Barcelona, IRB Barcelona is a Severo Ochoa Centre of Excellence—a seal that was awarded in 2011. The institute is devoted to conducting research of excellence in biomedicine and to transferring results to clinical practice, thus improving people’s quality of...
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Postdoctoral Fellows in Stem Cell Biology
hace 1 semana
Barcelona, España IRB Barcelona A tiempo completoCreated in 2005 by the Generalitat de Catalunya (Government of Catalonia) and the University of Barcelona, IRB Barcelona is a Severo Ochoa Centre of Excellence—a seal that was awarded in 2011. The institute is devoted to conducting research of excellence in biomedicine and to transferring results to clinical practice, thus improving people’s quality of...
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Postdoctoral Researcher in Computational Biology
hace 1 semana
Barcelona, España Vall d'Hebron Institute of Oncology (VHIO) A tiempo completo12 March 2021 **The Vall d´Hebron Institute of Oncology (VHIO) Seeks a “**Postdoctoral Researcher in Computational Biology**”** **Reference**:Ref. 17-2021 **Application deadline**:Application open until filled. **Number of vacancies**:1 **Job description**: The new Cancer Computational Biology group (PI Jose A. Seoane) at Vall d’Hebron Institute...
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Postdoctoral Position
hace 7 días
Barcelona, España Center for Genomic Regulation A tiempo completo**The Institute** The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by...
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Lab Technician Position in Chemical Biology
hace 5 días
Barcelona, España IRB Barcelona A tiempo completoCreated in 2005 by the Generalitat de Catalunya (Government of Catalonia) and the University of Barcelona, IRB Barcelona is a Severo Ochoa Centre of Excellence—a seal that was awarded in 2011. The institute is devoted to conducting research of excellence in biomedicine and to transferring results to clinical practice, thus improving people’s quality of...
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Barcelona, Barcelona, España Center for Genomic Regulation A tiempo completoThe InstituteThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end...
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Postdoc in Regulatory Genomics for Diabetes
hace 1 semana
barcelona, España Centre for Genomic Regulation A tiempo completoA leading biomedical research institute in Barcelona is seeking a motivated postdoctoral scientist to explore genome regulatory mechanisms in human diabetes. The ideal candidate will have expertise in molecular and cell biology, particularly in CRISPR techniques and next-generation sequencing. A BSc in a relevant field and a recent PhD are required. This...
