POSTDOCTORAL POSITION IN MOLECULAR BIOLOGY
hace 9 horas
Organisation/Company Institute of Neurosciences Research Field Neurosciences » Neurobiology Researcher Profile Recognised Researcher (R2) Positions Postdoc Positions Country Spain Application Deadline 30 Jan 2026 - 23:59 (Europe/Madrid) Type of Contract Temporary Job Status Full-time Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? NoOffer Description We are looking for Postdoctoral researchers to join the research group “Molecular Biology of Huntington’s disease” leaded by Dr. Veronica Brito at the Department of Biomedicine Institute of Neuroscience, University of Barcelona and Institut de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS).Brito’s lab’s main goal is to elucidate the molecular and cellular mechanisms by which the mutant Huntington’s disease gene drives selective neurodegeneration and to translate this knowledge into novel therapeutic strategies. Huntington’s disease (HD) is a fatal, inherited neurodegenerative disorder caused by an expanded CAG repeat in the HTT gene, leading to cognitive, motor, and psychiatric disturbances in patients. While somatic CAG-repeat expansion is recognized as an early event in HD pathogenesis, it remains to be fully understood how this DNA-level mutation gives rise to neuronal pathology. Several evidences have revealed that aberrant RNA processing and the production of HTT1a, a toxic truncated transcript, play key roles in disease progression. The postdoctoral researcher will join the team to contribute to an ongoing, cutting-edge project that builds on our recently published findings suggesting that N6- methyladenosine (m6A) marks on HTT RNA contribute to the generation of toxic HTT1a transcripts. The project aims to investigate how this RNA modification regulates the pathogenic HTT1a transcript in HD, elucidating the molecular links between m6 A deposition, DNA repair, transcriptional dynamics, and aberrant RNA processing within HTT. By defining the role of m6A RNA modifications as a novel layer of gene expression regulation—both at the disease locus and transcriptome-wide—this work seeks to uncover fundamental mechanisms of disease and lay the groundwork for innovative RNA-targeted therapeutic approaches in HD. The project integrates advanced RNA-mapping technologies (Direct RNA sequencing using Oxford Nanopore Technology) and CRISPR-based RNA editing tools to define how m6A controls HTT1a expression and to develop new strategies for precise epitranscriptomic modulation in disease models. This position focuses on experimental investigation of the molecular mechanisms underlying HTT1a expression in Huntington’s disease. The successful candidate will lead the design and execution of molecular and cellular assays, including RNA–protein interaction studies, RNA modification detection, DNA-RNA interaction and DNA repair assays as well as functional validation of bioinformatic predictions in cellular and mouse models.#J-18808-Ljbffr
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POSTDOCTORAL POSITION IN MOLECULAR BIOLOGY
hace 24 horas
Barcelona, España EURAXESS Ireland A tiempo completoOrganisation/Company Institute of Neurosciences Research Field Neurosciences » Neurobiology Researcher Profile Recognised Researcher (R2) Positions Postdoc Positions Country Spain Application Deadline 30 Jan 2026 - 23:59 (Europe/Madrid) Type of Contract Temporary Job Status Full-time Is the job funded through the EU Research Framework Programme? Not funded...
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Barcelona, España IQS A tiempo completoApplications are invited for the position of Postdoctoral Scientist at the Institut Químic of Sarrià (IQS) in Barcelona.Los candidatos deben tomarse el tiempo de leer atentamente todos los elementos de este anuncio de empleo. Por favor, envíen su solicitud sin demora.The project, funded by the US Department of Defense, focuses on developing new...
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Postdoctoral Fellow
hace 1 día
Barcelona, España European Molecular Biology Laboratory A tiempo completoPostdoctoral Fellowships - Barcelona, Spain he European Molecular Biology Laboratory (EMBL) is one of the highest ranked scientific research organizations in the world. The newest EMBL site is located in the Barcelona Biomedical Research Park (PRBB), one of the largest infrastructures in Southern Europe dedicated to translational research. The main focus...
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Postdoctoral Fellow On Molecular/cell Biology
hace 7 días
Barcelona, España IRB Barcelona A tiempo completoCreated in 2005 by the Generalitat de Catalunya (Government of Catalonia) and the University of Barcelona, IRB Barcelona is a Severo Ochoa Centre of Excellence—a seal that was awarded in 2011. The institute is devoted to conducting research of excellence in biomedicine and to transferring results to clinical practice, thus improving people’s quality of...
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Plaça de Postdoctoral Position in Bioinformatics
hace 1 semana
Barcelona, España Centre de Regulació Genòmica (CRG) A tiempo completoCentre de Regulació Genòmica (CRG). 1 plaça de Postdoctoral position in bioinformatics. Concurs o valoració de mèrits. Laboral temporal. 2024-09-15. Termini obert. A1 - Grau universitari (correspondència amb llicenciatures). Doctorat en Ciències Biològiques, Biologia Molecular, Biologia Computacional, Bioinformàtica, o camps relacionats. Bon...
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Plaça de Postdoctoral Fellow On Molecular/cell
hace 7 días
Barcelona, España Institut de Recerca Biomèdica (IRB) A tiempo completoInstitut de Recerca Biomèdica (IRB). 1 plaça de Postdoctoral Fellow on Molecular/Cell Biology. Concurs o valoració de mèrits. Laboral temporal. 2024-12-18. Termini obert. A1 - Grau universitari (correspondència amb llicenciatures). Llicenciat en Biociències. Doctor en Farmacologia, Biologia Molecular o Cel-lular. Bon domini de la llengua anglesa Veure...
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Barcelona, España EURAXESS Ireland A tiempo completoA leading research institution in Barcelona is seeking a postdoctoral researcher to join a team focused on the molecular biology of Huntington's disease. The successful candidate will investigate how RNA modifications influence gene expression using advanced technologies. This role involves designing and conducting experiments, including RNA-protein...
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Postdoctoral Fellows in Stem Cell Biology
hace 2 semanas
Barcelona, España IRB Barcelona A tiempo completoCreated in 2005 by the Generalitat de Catalunya (Government of Catalonia) and the University of Barcelona, IRB Barcelona is a Severo Ochoa Centre of Excellence—a seal that was awarded in 2011. The institute is devoted to conducting research of excellence in biomedicine and to transferring results to clinical practice, thus improving people’s quality of...
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Barcelona, España EURAXESS Ireland A tiempo completoA leading research institution in Barcelona is seeking a postdoctoral researcher to join a team focused on the molecular biology of Huntington's disease.¿Es usted el solicitante adecuado para esta oportunidad? Descúbralo leyendo el resumen del puesto a continuación.The successful candidate will investigate how RNA modifications influence gene expression...
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Barcelona, España Institute for Bioengineering of Catalonia (IBEC) A tiempo completoA leading research institute in Barcelona seeks a Postdoctoral Researcher to investigate PTEN gene variants using CRISPR technology in C. elegans. The role offers a full-time 18-month contract focused on interdisciplinary research and requires a PhD in biology or related field. Candidates must have experience in molecular biology techniques and a strong...
