PhD Position in Biomaterials for Neural Regeneration Research

hace 1 semana


Barcelona, Barcelona, España Institute for Bioengineering of Catalonia (IBEC) A tiempo completo
Introduction

The Institute for Bioengineering of Catalonia (IBEC) is seeking a highly motivated PhD candidate to join our multidisciplinary research team in the Biomaterials for Neural Regeneration group. This fully funded PhD position is part of an innovative project focused on developing advanced extracellular matrix (ECM) platforms for iPSC-derived spinal cord organoids.

Project Overview

This PhD project aims to address current limitations in iPSC-based models of the spinal cord by developing and applying ECM biomaterials tailored to specific stages of spinal cord development and disease modeling. The research involves creating structured scaffolds and synthetic matrices to enhance the growth, maturation, and functionality of spinal cord organoids and motor neurons derived from iPSCs.

Main Tasks and Responsibilities
  1. Design and Development: Create novel ECM platforms, including hydrogel-based matrices with bioactive sequences and structured scaffolds, to mimic the physiological conditions of the spinal cord environment at various developmental stages.
  2. Characterization and Optimization: Perform a comprehensive biochemical, structural, and functional analysis of the developed ECM platforms using state-of-the-art techniques such as mass spectrometry-based proteomics, single-cell RNA sequencing, and electrophysiological assessments.
  3. Application in Disease Modeling: Utilize the optimized ECM platforms to advance the fidelity of iPSC-derived spinal cord models for studying neurodevelopmental and neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA).
Requirements for Candidates

We are looking for a highly motivated PhD candidate who is eager to engage in interdisciplinary research in the fields of biomaterials, tissue engineering, and neuroscience. The ideal candidate would meet the following criteria:

  • Educational Background: A Master's degree in Biomedical Engineering, Neuroscience, Tissue Engineering, or a closely related field is preferred.
  • Laboratory Experience and Technical skills: Experience working in a wet lab setting is highly recommended. Familiarity with biomaterials, stem cell culture, or 3D biofabrication techniques would be advantageous.
  • Teamwork and Communication: We value candidates who enjoy working collaboratively in a multidisciplinary team, have strong problem-solving skills, and can effectively communicate their research findings through both oral and written presentations.
What We Offer

As a PhD researcher at IBEC, you will have the opportunity to gain hands-on experience with advanced biofabrication and biomaterials engineering techniques, work in a cutting-edge research environment with access to state-of-the-art equipment and facilities, and collaborate with leading experts in the fields of stem cell biology, neuroscience, and biomedical engineering.

We offer a full-time 4-year contract, measures to reconcile work and family life, and a yearly training catalogue with a wide range of training in technical and transferable skills. Additionally, we provide support and guidance in publishing your work in peer-reviewed journals and presenting at international conferences.



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