PhD Position in Biomaterials for Neural Regeneration Research Group

hace 1 semana


Barcelona, Barcelona, España Institute for Bioengineering of Catalonia (IBEC) A tiempo completo
Introduction

The Institute for Bioengineering of Catalonia (IBEC) is seeking a highly motivated PhD candidate to join our multidisciplinary research team in the Biomaterials for Neural Regeneration group. This fully funded PhD position is an exciting opportunity to contribute to innovative research in the field of biomaterials and neural regeneration.

Project Overview

This PhD project aims to develop advanced extracellular matrix (ECM) platforms for iPSC-derived spinal cord organoids. The research involves creating structured scaffolds and synthetic matrices to enhance the growth, maturation, and functionality of spinal cord organoids and motor neurons derived from iPSCs.

Main Tasks and Responsibilities
  • Design and Development: Create novel ECM platforms, including hydrogel-based matrices with bioactive sequences and structured scaffolds, to mimic the physiological conditions of the spinal cord environment at various developmental stages.
  • Characterization and Optimization: Perform a comprehensive biochemical, structural, and functional analysis of the developed ECM platforms using state-of-the-art techniques such as mass spectrometry-based proteomics, single-cell RNA sequencing, and electrophysiological assessments.
  • Application in Disease Modeling: Utilize the optimized ECM platforms to advance the fidelity of iPSC-derived spinal cord models for studying neurodevelopmental and neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA).
Requirements
  • Essential: A Master's degree in Biomedical Engineering, Neuroscience, Tissue Engineering, or a closely related field.
  • Laboratory Experience and Technical skills: Experience working in a wet lab setting is highly recommended. Familiarity with biomaterials, stem cell culture, or 3D biofabrication techniques would be advantageous.
  • Teamwork and Communication: We value candidates who enjoy working collaboratively in a multidisciplinary team, have strong problem-solving skills, and can effectively communicate their research findings through both oral and written presentations.
What We Offer
  • Number of available positions: 1
  • Starting date: January 2025
  • Gain hands-on experience with advanced biofabrication and biomaterials engineering techniques.
  • Work in a cutting-edge research environment with access to state-of-the-art equipment and facilities.
  • Collaborate with leading experts in the fields of stem cell biology, neuroscience, and biomedical engineering.
  • Opportunity to contribute to high-impact research with potential applications in regenerative medicine and disease modeling.


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