Postdoctoral Researcher in Enzyme Engineering and Synthetic Biology

hace 3 semanas


Barcelona, Barcelona, España Iqs - Universitat Ramon Llull A tiempo completo

Research Opportunity at IQS-Universitat Ramon Llull

We are seeking a highly talented postdoctoral researcher to join our team at the Institut Químic de Sarrià, University Ramon Llull in Barcelona.

The successful candidate will be involved in collaborative projects on protein engineering of carbohydrate active enzymes in biocatalysis and synthetic biology.

The project aims to develop engineered glycosidase enzymes/un-natural glycoconjugate substrates pairs for the bio-orthogonal and selective in vivo unmasking of probes/metabolites/labeling agents by the genetically-encoded engineered hydrolase for metabolic labeling and microbiome studies.

This is a collaborative project between the Planas Lab at IQS-URL, Barcelona (enzyme engineering and chemical biology) and the Peczuh's Lab at the University of Connecticut, USA (synthetic carbohydrate chemistry).

The researcher will be responsible for designing and implementing diverse bio-orthogonal engineered glycosidase/un-natural glycoconjugate substrate pairs, involving state-of-the-art protein design and engineering by directed evolution approaches, development of high-throughput screening methods, biochemical characterization of engineered variants for specificity and bio-orthogonality on designer unnatural glycoside conjugates.

The project envisages proof-of-concept applications in microbiome studies (engraftment of a specific strain into a microbiome) and metabolic labeling (bacterial cell wall polysaccharides biosynthesis).

Requirements:

  • PhD in a relevant field
  • Experience in protein engineering and biocatalysis
  • Strong background in carbohydrate chemistry and synthetic biology
  • Excellent communication and teamwork skills

What We Offer:

  • A dynamic and collaborative research environment
  • State-of-the-art facilities and equipment
  • Opportunities for professional growth and development

How to Apply:

Please submit your application, including your CV and a cover letter, to [insert contact information].



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