Postdoctoral Researcher Position in Protein Engineering

hace 4 semanas


Barcelona, Barcelona, España Iqs - Universitat Ramon Llull A tiempo completo

Postdoctoral Researcher Position in Protein Engineering

We are seeking a highly talented researcher to join our team at the Institut Químic de Sarrià, University Ramon Llull in Barcelona. The successful candidate will be involved in collaborative projects on protein engineering of carbohydrate active enzymes in biocatalysis and synthetic biology.

The postdoctoral researcher will lead the project: New-to-nature glycosidases as bio-orthogonal tools in metabolic labeling and microbiome studies. This project aims at developing engineered glycosidase enzymes/un-natural glycoconjugate substrates pairs for the bio-orthogonal and selective in vivo unmasking of probes/metabolites/labeling agents by the genetically-encoded engineered hydrolase for metabolic labeling and microbiome studies.

This is a collaborative project between the Planas Lab at IQS-URL, Barcelona (enzyme engineering and chemical biology) and the Peczuh's Lab at the University of Connecticut, USA (synthetic carbohydrate chemistry). The project envisages proof-of-concept applications in microbiome studies (engraftment of a specific strain into a microbiome) and metabolic labeling (bacterial cell wall polysaccharides biosynthesis).

The successful candidate will be responsible for the design and implementation of diverse bio-orthogonal engineered glycosidase/un-natural glycoconjugate substrate pairs. This will involve state-of-the-art protein design and engineering by directed evolution approaches, development of high-throughput screening methods, biochemical characterization of engineered variants for specificity and bio-orthogonality on designer unnatural glycoside conjugates for subsequent implementation to the relevant proof-of-concept applications.



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