Postdoctoral Researcher in Enzyme Engineering

hace 1 día


Barcelona, Barcelona, España Iqs - Universitat Ramon Llull A tiempo completo
Postdoctoral Researcher Position at IQS-Universitat Ramon Llull

We are seeking a highly talented postdoctoral researcher to join our team at the Institut Químic de Sarrià, University Ramon Llull in Barcelona. The successful candidate will be involved in collaborative projects on protein engineering of carbohydrate active enzymes in biocatalysis and synthetic biology.

Project Overview

The postdoctoral researcher will lead the project: New-to-nature glycosidases as bio-orthogonal tools in metabolic labeling and microbiome studies. This project aims to develop engineered glycosidase enzymes/un-natural glycoconjugate substrates pairs for the bio-orthogonal and selective in vivo unmasking of probes/metabolites/labeling agents by the genetically-encoded engineered hydrolase for metabolic labeling and microbiome studies.

Key Responsibilities
  • Design and implementation of diverse bio-orthogonal engineered glycosidase/un-natural glycoconjugate substrate pairs
  • State-of-the-art protein design and engineering by directed evolution approaches
  • Development of high-throughput screening methods
  • Biochemical characterization of engineered variants for specificity and bio-orthogonality on designer unnatural glycoside conjugates
Collaboration and Training

The project is a collaborative effort between the Planas Lab at IQS-URL, Barcelona (enzyme engineering and chemical biology) and the Peczuh's Lab at the University of Connecticut, USA (synthetic carbohydrate chemistry). The postdoctoral researcher will have the opportunity to work with experienced researchers and gain expertise in protein engineering, biocatalysis, and synthetic biology.

Requirements

We are looking for a highly motivated and talented researcher with a strong background in protein engineering, biocatalysis, and synthetic biology. The ideal candidate will have a PhD in a relevant field and experience in protein design and engineering, biochemical characterization, and high-throughput screening methods.



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