Postdoctoral Research Assistant For The Computational Oncology Group
hace 5 días
About The Role:
As a postdoctoral researcher in our group, you will work closely with lab members and clinical collaborators to develop and apply computational methods for analysing whole-genome sequencing data. Your primary focus will be on identifying different types of chromosomal instability and matching them with targeted therapies.
Key Responsibilities:
• Develop and apply computational algorithms for decomposing patterns of chromosomal instability at unprecedented resolution and at different timepoints of tumour evolution.
• Process sequencing data from 50,000 tumour genomes and reformulate features to encode patterns of copy number changes at base-pair resolution.
• Characterise new chromosomal instability signatures by integrating orthogonal data and elucidate the underlying biology of these signatures.
• Design a web-based tool for leveraging these advances and assisting users to accurately identify and quantify mutational processes operating in new tumour samples.
Requirements:
• PhD degree in bioinformatics, computational biology, computer science, mathematics, physics or statistics.
• Proven expertise in bioinformatics, particularly in cancer genomics, tumour evolution and mutational signature analysis.
• Experience in analysing whole genome sequence data and coding experience (preferably in R and Python).
• Familiarity with high performance and/or cloud computing.
What We Offer:
The Macintyre Lab strives to provide a supportive, flexible and fun working environment, free from bias and inequality, to promote the next generation of scientists. We welcome members from all backgrounds who are passionate about research and are interested in translating their work for patient benefit.
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