Postdoctoral Research Assistant for Computational Oncology

hace 2 días


Zaragoza, Zaragoza, España Cnio A tiempo completo
Postdoctoral Research Assistant for Computational Oncology

The Computational Oncology Group at the Spanish National Cancer Centre (CNIO) is seeking a highly skilled postdoctoral researcher to join our team. As a postdoctoral research assistant, you will play a key role in developing computational approaches to guide the chemoprevention of cancer.

About the Project

We are using single cell DNA sequencing and computational approaches to identify different types of chromosomal instability and match them with targeted therapies. Our goal is to prevent the development of aggressive, difficult to treat cancers. We have recently pioneered an innovative computational algorithm capable of dissecting different chromosomal instability (CIN) types in a tumour and demonstrated its potential for predicting response to existing therapies.

Responsibilities
  • Develop new AI methodologies to process sequencing data from 50,000 tumour genomes
  • Reformulate features to encode patterns of copy number changes at base-pair resolution
  • Decompose CIN in the new feature space by applying deep-learning approaches
  • Characterise signatures by integrating orthogonal data
  • Design a web-based tool for leveraging these advances
Requirements
  • PhD degree in bioinformatics, computational biology, computer science, mathematics, physics or statistics
  • Proven expertise in bioinformatics, particularly in cancer genomics, tumour evolution and mutational signature analysis
  • Experience in analysing whole genome sequence data
  • Coding experience (preferably in R and Python)
  • Experience with high performance and/or cloud computing
  • Manuscript writing
About the Lab

The Macintyre Lab strives to provide a supportive, flexible and fun working environment, free from bias and inequality, to promote the next generation of scientists. We welcome members from all backgrounds who are passionate about research and are interested in translating their work for patient benefit.



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