Molecular Diagnostics Science Manager in Ctdna

hace 3 semanas

Barcelona, España AstraZeneca A tiempo completo

AstraZeneca delivers companion and complementary diagnostic assays that match medicines to those patients who are most likely to benefit from them. This approach, known as **Precision Medicine**, is based on those individual characteristics that make some patients respond to treatment better than others. We use this knowledge to develop diagnostic tests that doctors can use to help prescribe the best treatment for each patient.

As a **Manager**,** **Molecular Diagnostics** Science** **in ctDNA Diagnostics, you will use your knowledge of ctDNA and other cutting-edge technologies and approaches (Next Generation Sequencing (NGS), Whole Genome Sequencing (WGS), Whole Exome Sequencing (WES), Minimal Residual Disease (MRD) etc.) to provide **scientific** and** **t**echnical **expertise** to deliver innovative ctDNA diagnostic approaches to AstraZeneca’s clinical portfolio, through strategic partnerships with leading diagnostic companies.

**The** role holder will be** accountable for**:

- Overseeing the delivery of ctDNA diagnostic science and innovation projects, through close collaboration with the cross-functional ctDNA team
- Building and maintaining a knowledge of current and emerging technologies in ctDNA diagnostics, with a particular focus on oncology, and identifying opportunities for innovation and internal/external collaborations
- Evaluating the performance of novel ctDNA diagnostics for prognosis and Minimal Residual Disease, through delivery of diagnostic feasibility and harmonisation studies
- Developing innovative ctDNA diagnostic science proposals across core therapeutic areas
- Providing scientific and strategic input into ctDNA-based precision medicine approaches for diagnostic and drug product teams
- Ensuring that all activities are delivered demonstrating behaviours and values aligned to AstraZeneca Code of Conduct and supporting policies, standards and procedures, including compliant management of Budget, Safety, Health and Environment

**Typical Accountabilities, what you will be doing**:
**Strategic direction**
- Make a marked contribution to overall ctDNA diagnostic strategy to identify and evaluate diagnostic partners who can further the mission of AZ diagnostic and drug product teams
- Deliver scientific and strategic advice to the development and execution of ctDNA diagnostic science projects and feasibility studies to inform internal decision-making, as well as address barriers to meet the needs of patients, physicians, regulators and payers and add value to AZ drug products
- Obtain and manage investment to enable ctDNA diagnostic innovation and science work packages
- Deliver expert advice of high scientific quality on ctDNA diagnostic testing options for precision medicine approaches and companion diagnostic development to relevant product teams

**Leadership**
- Provide leadership for delivery of ctDNA diagnostic science within AstraZeneca’s Precision Medicine and Biosamples department, including communication of a clear and inspirational vision for ctDNA diagnostic science strategy
- Draw upon previous experience and expert knowledge to provide and maintain a relevant knowledge base of ctDNA diagnostic development and new technologies for the Molecular Diagnostics, Precision Medicine and project teams

**Planning, Monitoring and Delivering**
- Ensure delivery of objectives and milestones for ctDNA diagnostic innovation and science projects, including sourcing and tracking of human biological samples for feasibility studies and managing collaborations
- Accountable for the delivery of ctDNA diagnostic innovation and science projects to time, budget and quality

**Assessing and Managing Risk**
- Provide regular updates on progress, risks, issues and opportunities to Molecular Diagnostic team, ctDNA team, governance bodies or leadership teams as required
- Work with Molecular Diagnostics leadership team to resolve resource, quality and budget issues
- Manage risk in an appropriate and compliant manner
- Ensure compliance with all AstraZeneca Policies and Standards and immediately address instances of non-compliance

**Governance processes and stakeholder interactions**
- Provide data to senior leaders and to governance bodies as required
- Ensure that all governance issues are identified and reported appropriately

**Education, Qualifications, **Skills** and Experience**:
**Essential**:

- Record of delivery in a scientific capability
- Leadership ability and global team working
- Excellent molecular biology skills including experience in Next-Generation Sequencing (NGS), ctDNA, DNA and RNA handling methods and other relevant molecular biology, genomics and/or epigenomics techniques
- Excellent knowledge of current technology trends in ctDNA diagnostics
- Excellent knowledge of scientific literature with deep understanding in molecular biology, ctDNA diagnostics, demonstrated through publications in peer reviewed journals
- Experience of leading projects within a molecular bi

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