Bioinformatician - Single Cell Epigenomics and

hace 2 meses

Barcelona, España Center for Genomic Regulation A tiempo completo

**The Institute**

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.
In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).

Please, check out our Recruitment Policy

**The role**

**About the lab**

Tumors originate from normal cells that acquire tumor-initiating genetic events, such as translocations and somatic mutations. These genetic hits turn normal cells into pre-malignant cells, but do not lead to immediate tumor formation. For that, secondary genetic events as well as epigenetic hits are required.

We aim to create a better understanding of how epigenetic tumor-associated changes arise in the context of non-Hodgkin lymphomas. To that end, we aim to study the occurrence of these changes in healthy individuals as well as in pre-malignant cells in vitro (to be created by CRISPR/Cas9 genomic editing) and in vivo using single-cell technologies. On top of that, we aim to define cell intrinsic mechanisms, such as enhancer activation and 3D chromatin interactions, that influence the occurrence of the observed changes.

**Whom would we like to hire?**

**Professional experience**

**Must Have**
- You have good knowledge of Computational Biology
- You have a strong background in the analysis of epigenetic (e.g. ChIP-seq, ATAC-seq, DNA methylation data, chromatin conformation capture data) and/or single-cell (RNA-seq or ATAC-seq) data

**Desirable but not required/ Nice to have**
- You have experience in data analysis of genome-wide genetic datasets and RNA-seq

**Education and training**

We are looking for a bioinformatician with one of the following levels of education/training:

- A master’s degree in Bioinformatics or a related discipline and at least 1 year of experience in performing bioinformatic analysis
- A master’s degree or PhD in the life sciences or computer science field and at least 3 years of experience in performing bioinformatic analysis

**Languages**
- You are fluent in English

**Technical skills**
- You have practical experience in:

- NGS data-analysis
- Single-cell technology-based data analysis
- Genome-wide epigenetic data analysis- You have advanced Unix operating systems skills
- You are competent in Python, Perl or R

**Competences**
- You have highly developed organization skills
- You have excellent analytical and problem-solving skills
- You have enthusiasm, motivation and dedication to explore new scientific avenues
- You have the capability to work on different projects simultaneously as part of a team and/or independently

**The Offer - Working Conditions**
- **Contract duration**: 2 year and 8 months, linked to plan estatal project, with the possibility of extension.
- **Estimated annual gross salary**: Salary is commensurate with qualifications and consistent with our pay scales.
- **Target start date**: January 2023.

We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section.
We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity.
The CRG is committed to reconcile a work and family life of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.

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