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Bioinformatician
hace 3 meses
.UbicaciónBarcelona, Barcelona provinciaDescripción completa del empleoThe InstituteThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).The roleWe are seeking a highly motivated Bioinformatician to join the Epitranscriptomics and RNA Dynamics group (PI: Eva Novoa), to study the role of RNA modifications (the "epitranscriptome") using nanopore sequencing technologies.Your work would be part of the project "Systematic analysis of RNA modification dynamics upon neuronal activation and differentiation using nanopore sequencing", which has been funded by the Ministerio de Ciencia e Innovación (Plan Nacional). We aim to study how RNA modifications change during neuronal differentiation and activation and what role they play in neuronal plasticity.Our laboratory has been a pioneer in the use of native RNA nanopore sequencing to study RNA modifications, including the development of novel algorithms to map and quantify RNA modifications using nanopore sequencing.The candidate will be responsible for leading the bioinformatics work related to the project, including the development of novel algorithms to analyze RNA modifications, quantify them, study their differential RNA modification patterns, etc. In addition, the candidate will provide general bioinformatics support to the team.About the labOur lab is focused on deciphering the role that RNA modifications play in a variety of cellular contexts, including the development of novel technologies to map RNA modifications. We employ a combination of experimental (RNASeq, RIP-Seq polysome profiling, mouse/cell knockouts, Oxford Nanopore direct RNA sequencing) and computational techniques (NGS data analysis, algorithm development, machine learning) to unveil the secrets of three post-transcriptional regulatory layers: the epitranscriptome, RNA structure, and ribosome specialization.Whom would we like to hire?Professional experienceTo be successful in this application, you will be an analytical thinker with a background in Computational Biology (ideally related to RNA biology) and high-level skills in Bioinformatics
