Assistant Research

Offer DescriptionIdiPAZ Seeksa research assistant in a research project co-financed by the Community of Madrid and the European Social Fund Plus (ESF+), *********, for the Pediatric Extracranial Solid Tumors group, led by Dr. Adriana Mañas, and part of the Translational Research in Childhood Cancer, Hematopoietic Transplantation, and Cell Therapy (GICITT) group, led by Dr. Pérez-Martínez, within the Biomedical Research Foundation of La Paz University Hospital (IdiPAZ).

The candidate will participate directly in the projects led by Dr. Mañas, especially in the paediatric avatars project, focused on the creation and characterisation of patient-derived models (in-vivo and in-vitro) and their use as avatars to develop new personalised treatments for paediatric solid tumours (neuroblastoma, hepatoblastoma, nephroblastoma and sarcoma).

IdiPAZ Health Research Institute is the result of a partnership between "La Paz" University Hospital, Universidad Autónoma de Madrid, the Healthcare Public Service of the Madrid Autonomous Region and the Foundation for Biomedical Research of La Paz University Hospital (FIBHULP), which is the managing body of the Institute.

This strategic alliance has made it possible to tackle research projects through joint multidisciplinary teams, making the most of the human and material resources available to these entities for research and promoting research fundraising.

Our vision is to be a national and international reference for biomedical translational research of excellence, focus on people's health.Where to applyE-mail ****** Field Biological sciences » Biology Education Level Master Degree or equivalentSpecific RequirementsThe candidate will participate directly in the projects led by Dr. Mañas, especially in the paediatric avatars project, focused on the creation and characterisation of patient-derived models (in-vivo and in-vitro) and their use as avatars to develop new personalised treatments for paediatric solid tumours (neuroblastoma, hepatoblastoma, nephroblastoma and sarcoma).

• Implantation of patient tumour samples in immunosuppressed mice (PDX models).
• Treatment of PDX models with chemotherapy and characterisation of tumour response by RNA analysis and histological techniques.
• Establishment of in-vitro organoid models from PDX models and characterisation of the response to chemotherapy in vitro.
• Use in-vitro (organoid) and in-vivo (PDX) models to test and validate new therapies in comparison with standard chemotherapy.The activities and functions to be performed by the candidate:- Processing of patient tumour samples, both to preserve viability and for implantation in animals.
• Collaborate in the process of PDX implantation, monitoring and treatment of mice, and collection and processing of tumours for different analyses.
• Establish in-vitro PDX-derived tumour organoid cultures.
• Extraction and basic bioinformatics analysis of RNA from tumours and organoids.
• Processing of tumours and organoids for histological analysis.
• Treatment of tumour organoids with different therapies and analysis of viability and cytotoxicity.Experience- Previous experience in cell culture.
• Basic experience in biomolecular analysis techniques such as Western Blot, DNA/RNA extraction, PCR, etc.- High level (C1) of spoken and written English.
• Advanced knowledge of Microsoft Office (Word, Excel, Powerpoint).
• Previous experience in tumour organoid culture (positive assessment).
• Experience with paediatric cancer models.
• Possession of a certificate for working with animals (Functions A, B and C).
• Knowledge of specific software such as GraphPad, FlowJo or ImageJ.Essential requirements for candidates to be eligible for the offer as set out in the call for applications:- Be under 30 years of age on the date of contracting with the beneficiary entity.
• Be unemployed until the day before the date of contracting with the beneficiary entity.
• Have no other employment contract from the date of contracting.Languages ENGLISH Level ExcellentAdditional Information- Contract for scientific and technical activities.
• Professional category of Higher Graduate or Graduate, Group II, Area 2, according to the collective bargaining agreement.
• Full time of 37.5 hours per week.
• Gross annual salary: €******.- Private matters: 6 working days per year.
• Vacation: 22 working days per year.
• December 24 and 31 are non-business days.Eligibility criteriaThe selection process will consist of two phases and the following scale will be applied, out of a maximum of 10 points:- Training and curricular merits: 6 points.
• Personal interview: 4 points.In the event that two or more candidates match the values and needs of the institution and meet the conditions required for the post, and where there is a tie, the candidate with a certificate attesting to a minimum degree of disability equal to or greater than 33 per cent shall prevail.Selection processOnce candidates send their application to the IdiPAZ e-mail address, their applications are stored until the deadline for receipt of applications for the offer is up.

The HR department of IdiPAZ will make a first selection of applications selecting those who meet the criteria required in the offer.

The selected applications are then evaluated by the selection committee, composed of the head of human resources at IdiPAZ, the President of the IdiPAZ Internal Scientific Committee and the Project Manager which will apply the scales described in each call for applications.

Once the candidate is selected, he/she will be contacted by the HR department of IdiPAZ to provide the required documentation.Additional commentsContract co-financed by the Community of Madrid and the European Social Fund Plus (ESF+), *********, with reference PEJ-****-AI/SAL-GL-*****.Applications shall be submitted in the following manner:- Send CV to ******.

In the subject of the e-mail, please indicate the reference "Assistant Research (PEJ-****-AI/SAL-GL-*****) (AM)".

• Incorporation and place of work- Contract start date: 1 February ****.- Place of work: Foundation/IdiPAZ.
• Documentation to be submitted by each candidate:- Updated curriculum vitae.
• Document certifying academic qualifications.
• Voluntarily inform if you belong to a disadvantaged group or justify any possible career leaps.Collective Bargaining Agreement of the Group of Companies of the Biomedical Research Foundations of the Health Institutions attached to the Madrid Health Service (SERMAS).

Scales to be used to evaluate the applications (varies according to the offer).

Professional development opportunities within the institution: OTM-R Policy, IdiPAZ equal opportunity policies, Data Protection Manual.Work Location(s)Company/Institute: Fundación para la Investigación Biomédica del Hospital Universitario La PazCountry: SpainState/Province: MadridCity: MadridPostal Code: *****Street: Paseo Castellana 261#J-*****-Ljbffr