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Bioinformatician
hace 2 semanas
**Descripción**:
The Barcelona Institute for Global Health (ISGlobal) is a cutting-edge institute addressing global public health challenges through research, translation into policy and education. ISGlobal has a broad portfolio in communicable and non-communicable diseases including environmental and climate determinants, and applies a multidisciplinary scientific approach ranging from the molecular to the population level. Research is organized in the following main areas, Malaria and other Infectious Diseases, Maternal, Child and Reproductive Health, Urban Health, Child and Environmental health, and Climate & Non-Communicable Diseases. ISGlobal is accredited with the Severo Ochoa distinction, a seal of excellence of the Spanish Science Ministry.
**Lugar**:
Barcelona, Campus Clinic-CEK
**WHAT WE ARE LOOKING FOR**:
ISGlobal is seeking a Master’s level researcher in bioinformatics and data science to work on the malaria research projects performed by the Malaria Immunology Group. The overall goals are to identify molecular signatures correlating and predicting vaccine immunogenicity and protection against and understand the mechanisms and mediators of protective immunity induced by infection and vaccines using single-cell RNAseq and CITE-Seq methods and multidimensional clinical, epidemiological, immunological and molecular data.
**ABOUT THE POSITION**:
ISGlobal is seeking a researcher in bioinformatics to work on the project “Unravelling the heterogeneity and function of monocytes in vaccination and immunity to malaria (VaMonoS)”, project PID2022-140479OB-I00 funded by the Ministry of Science ( MCIN/AEI/10.13039/501100011033/ FEDER, UE).
The aim of this project is to decipher the molecular, phenotypic and functional profiles of monocyte subsets associated with vaccine immunogenicity and induced protection. Ultimately, the goal of this project is to improve the health of people, particularly those responding poorly to vaccines, through the generation of novel knowledge on monocytes immunology.
**SPECIFIC REQUIREMENTS**:
- Bioinformatics expertise in omics analysis is essential
- Previous expertise in malaria and immunology research
- Knowledge of predictive analysis, modeling and machine learning is required to analyze complex immunological data sets
- Advanced bioinformatics skills and programming, preferably with R
- Experience with database management software including R
- Experience/knowledge in analysing complex multidimensional data using machine learning methods
- Motivated researcher capable of setting and meeting deadlines and delivering research outputs to the required standard
**KEY RESPONSIBILITIES**:
- Management and analysis of data generated in single-cell RNAseq, CITE-seq and ATAC-Seq experiments in relation to malaria vaccination and infection.
- Integration of single-cell data with immunological, epidemiological and clinical datasets
- In addition, management and analysis of other OMIC data in relation to malaria immunity.
**SPECIFIC DUTIES**:
- Design, implement, manage relational databases
- Contribute to developing robust, standardized bioinformatic pipelines for single-cell techniques: scRNA-seq and CITE-Seq
- Perform the analysis of single-cell data generated in the group and integrate it with immunological, epidemiological and clinical data.
- Establish general quality controls, standards and good practices to ensure quality and reproducibility
- Provide training and support to the teams for the execution and analysis of specific experiments
- Carry out data cleaning and quality control,
- Document and archive all data for easy use in future research
- Conduct statistical analyses of the data using specialised bioinformatics software for immunology studies
- Prepare data reports and manuscripts
**AUXILIAR TASKS**:
This job description reflects the present requirements of the post but may evolve at any time in the future as duties and responsibilities change and/or develop providing there is appropriate consultation with the post-holder.
**SKILLS**:
- Outstanding organizational and team-working skills (yet capable of working independently).
- Responsible, flexible and with problem solving skills.
- Eager to learn, proactive and with great initiative.
- Capability of setting and meeting deadlines.
- Demonstrable adaptability and flexibility to adapt positively to changes.
- Availability to travel as required by project activities.
The post holder will adhere to ISGlobal principles contained in People management policy, including Equity, diversity and health safety. The post holder will respect, and accountable to ensure ISGlobal policies and procedures.
**LANGUAGE LEVEL**:
- Proficiency in English (written and spoken)
- Knowledge of Spanish and/or Catalan would be an asset.
**CONDITIONS**:
- Duration: 12 months (with the possibility of extension pending successful evaluations).
- Starting date: October 2025
- Contract: Full-time.
- Salary Range: According to ex
