Discovery DMPK Lead
hace 13 horas
Discovery DMPK Lead (m/f/d) – Grünenthal Group Professional | Permanent | Full-time | Hybrid If you’re passionate about changing lives for the better, this is the opportunity you’ve been waiting for. In Research & Development , we’re continuously exploring innovative new treatment options to make a stronger, more positive impact on the lives of the patients we serve. You’ll work with talented colleagues in a state‑of‑the‑art Research & Development environment, developing innovative medicines that change the life of patients for the better and help us make progress towards our vision of a world free of pain. Join us today, and discover the difference you can make. What the Job Looks Like DMPK representative on project teams influencing project progression from target validation through to candidate selection and into preclinical development. For small molecule and oligonucleotide projects, lead the scientific and operational design, conduct, implementation, and analysis of DMPK, ADME and PKPD studies to support the progression of discovery projects towards candidate selection and preclinical development using state‑of‑the‑art computational, in vitro and in vivo technologies. Align with Medicinal Chemistry, Pharmacology, Genetic Medicines, Pharmaceutical Sciences and Clinical to ensure human PK, PKPD and dose predictions are undertaken to aid project decision making from target validation through to candidate selection for all modalities. Align with non‑clinical safety to integrate PK and metabolism understanding into safety risk assessment, interpretation and quantitation/prediction of therapeutic margin of candidate molecules. Engage with Development DMPK and Clinicians to ensure human PK, PKPD, ADME and DDI predictions of candidate molecules are sufficiently robust to be utilised effectively in early clinical study design and dose selection. Engage with CROs and external consultants regarding conduct and interpretation of both discovery and preclinical development DMPK studies. Keep abreast of DMPK science through literature and conferences and look to publish work where possible. What You’ll Bring To The Table Educated to degree or PhD level in biological or pharmacological sciences or related field with at least 7 years experience gained working in DMPK discipline in industry as a DMPK project representative on discovery and development projects. For small molecules, expert technical knowledge of ADME/DMPK principles particularly in drug discovery and good understanding of their relationship to drug design, pharmacology and PKPD. For oligonucleotides, sound understanding of DMPK and PKPD principles for these modalities and preferably some experience of oligonucleotide projects. Ability to design, initiate and oversee discovery DMPK/ADME studies at CROs with timely delivery of data and interpretation that drives DMPK optimisation. Track record of interpretation and reporting of DMPK studies to support decision making. Experienced in pharmacokinetic analysis with experience in use of software such as Phoenix/WinNonLin PK. Excellent written and communication skills. Demonstrated ability to work in a matrix environment, multi‑task, meet deadlines and deal with evolving priorities. “DMPK sciences plays a crucial role at the interface between preclinical and clinical development. At Grunenthal we are at an exciting phase of innovation of small molecules and genetic medicines for Pain R&D. Come join us in DMPK on this journey.” Paul Morgan, the Hiring Manager #J-18808-Ljbffr
-
Growth Marketing Manager
hace 3 días
Madrid, España Social Discovery Group A tiempo completoSocial Discovery Group (SDG) OverviewConsulte la descripción del puesto a continuación. Si confía en que tiene las habilidades y la experiencia adecuadas, envíe su solicitud hoy mismo.Social Discovery Group (SDG) is the 3rd largest social discovery company in the world, uniting 60+ brands with 500 million users. We solve the problems of loneliness,...
-
Growth Marketing Manager
hace 17 horas
Madrid, España Social Discovery Group A tiempo completoSocial Discovery Group (SDG) Overview Social Discovery Group (SDG) is the 3rd largest social discovery company in the world, uniting 60+ brands with 500 million users. We solve the problems of loneliness, isolation, and disconnection by transforming virtual intimacy into the new normal. Our portfolio includes online communication platforms focusing on AI,...
-
Expert Researcher in Discovery projects
hace 2 semanas
madrid, España ING A tiempo completoIn ING we are looking for an Expert Researcher in Discovery projects Your role and work environment: We're looking for researcher with a keen eye for social trends and high and proven experience in quantitative research projects to join the Research Team in our Customer Obsession & Innovation Center of Expertise. You'll design and manage research projects...
-
Senior Backend Engineer
hace 3 días
Madrid, España sennder A tiempo completo**Senior Backend Engineer | Discovery Team**: sennder is digitizing Europe's logistics. We are growing team looking for a Senior Software Engineer (Backend) to help us on our journey to revolutionize road freight logistics. You would join our Discovery (pod) team in Madrid our new Tech Hub in Barcelona. The Discovery team focuses on enabling carriers to keep...
-
Sr Director Localization Coe Spain
hace 7 días
Madrid, España Warner Bros. Discovery A tiempo completo**_Welcome to Warner Bros. Discoverythe stuff dreams are made of._** **Who We Are ** When we say, “the stuff dreams are made of,” we’re not just referring to the world of wizards, dragons and superheroes, or even to the wonders of Planet Earth. Behind WBD’s vast portfolio of iconic content and beloved brands, are the _storytellers_ bringing our...
-
Expert Researcher in Discovery projects
hace 7 días
Madrid, España ING A tiempo completoIn ING we are looking for an Expert Researcher in Discovery projects Your role and work environment: We're looking for researcher with a keen eye for social trends and high and proven experience in quantitative research projects to join the Research Team in our Customer Obsession & Innovation Center of Expertise. You'll design and manage research projects...
-
Strategy Lead
hace 2 semanas
Madrid, España The Cigna Group A tiempo completoStrategy Lead About Cigna: Let us tell you a little more about us. Cigna exists to improve lives. Together, with our 74,000 employees worldwide that service Cigna, Express Scripts and other affiliate customers, we aspire to transform health services, making them more affordable and accessible to millions. When you work with us, you’ll enjoy meaningful...
-
AI Solutions Lead
hace 7 días
Madrid, España Kelp Labs A tiempo completoAI Solutions Lead (Founding Team)No deje pasar esta oportunidad, inscríbase rápidamente si su experiencia y habilidades coinciden con lo que se indica en la siguiente descripción.---Sobre el rol (TL;DR)Buscamos a nuestro primer hire del founding team para liderar la intersección entre preventa técnica, diseño de soluciones y delivery de proyectos de IA...
-
Spanish Copywriter
hace 2 horas
Madrid, España Warner Bros. Discovery A tiempo completo**_Every great story has a new beginning, and yours starts here._** **_ Welcome to Warner Bros. Discoverythe stuff dreams are made of._** **Who We Are ** When we say, “the stuff dreams are made of,” we’re not just referring to the world of wizards, dragons and superheroes, or even to the wonders of Planet Earth. Behind WBD’s vast portfolio of...
-
Genomics project lead – r&d biotech
hace 4 semanas
Madrid, España Montse Codina Coach A tiempo completoMontse Codina Coach is recruiting on behalf of an international agri-food company, headquartered in the province of Barcelona, for a Genomics Project Lead to join its R& D Biotech team. Genomics Project Lead – R& D Biotech About the Role The Genomics Project Lead will lead genomics-driven projects focused on the identification of key genes and alleles that...
