Postdoctoral Scientist, Computational epigenomics and Genetics
hace 2 días
The Institute
The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated and creative scientific team supported by flexible and efficient administration and high-end innovative technologies.
In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to align practices and procedures with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).
Please check out our Recruitment Policy.
The role
We are seeking a motivated postdoctoral scientist to lead a project in one of these two areas:
Analysis and discovery of rare noncoding mutations causing diabetes, using advanced statistical genetics, computational regulatory genomics, and analysis of whole genome sequences in unique patient cohorts.
Using computational strategies to develop a high resolution epigenomic technology with translational potential.
About the lab
The Regulatory Genomics and Diabetes lab aims to uncover genetic mechanisms causing diabetes mellitus and to develop therapeutic avenues. The group is particularly interested in understanding how genomic information is used to direct cell-specific gene expression and to pinpoint gene regulatory defects underlying human disease.
The team brings together diverse expertise, including work with mutant stem cell-derived beta cell organoids, engineered mouse models, single cell epigenomics, large-scale genetic screens, statistical genetics, and the integration of genetic and regulatory data. This multidisciplinary approach provides unique opportunities for collaborative projects that combine experimental and computational methods.
Recent studies from the lab include:
A lineage-specific gene transcription and splicing hierarchy that is disrupted in type 2 diabetes. (In review).
Large-scale discovery of molecular targets for precision treatment of HNF1A-deficient diabetes. (In review).
Transcription regulation by long non-coding RNAs and its disease relevance (Nat Rev Mol Cell Biol, 2024).
HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A (Nat Cell Biol 2022).
Pancreas agenesis mutations disrupt a lead enhancer controlling a developmental enhancer cluster.(Dev Cell, 2022).
Human pancreatic islet 3D chromatin architecture provides insights into the genetics of type 2 diabetes (Nat Genet 2019).
Whom would we like to hire?
Professional experience
Must Have
You hold a PhD (or equivalent experience) in statistical genetics, genome or epigenome data analysis, or related fields.
You have proven programming competence in Python, R, or C++, or related languages, and expertise in Linux and high-performance computing environments.
You have proven experience in applying statistical methods to large datasets. Familiarity with methods in machine learning and/or statistical inference is desirable but not essential.
Experience in genome sequence variant data and/or statistical genetics is highly advantageous for engaging in a human variant analysis project. Experience in NGS data analysis is necessary for engaging in an epigenomics technology project.
Desirable but not required/ Nice to have
A first-author publication track record is highly advantageous.
A proven research track record in any other area of genome or epigenome data analysis is highly advantageous.
Education and training
You hold a PhD (or equivalent experience) in statistical genetics, genome or epigenome data analysis, or related fields.
Languages
You are fluent in English.
Competences
You desire and have the ability to work both collaboratively and independently within a multidisciplinary environment.
The Offer – Working Conditions
Contract duration: Contract for Technical and Scientific Activities – estimated duration of 2 years, with the possibility of renewal.
Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.
Target start date: January 2025.
We provide a highly stimulating environment with state-of-the-art infrastructures and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section.
We offer and promote a diverse and inclusive environment and welcome applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation, or gender identity.
The CRG is committed to reconciling a work and family life of its employees and offers an extended vacation period and the possibility to benefit from flexible working hours.
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Barcelona, España Centre For Genomic Regulation A tiempo completo.You are here: Home > Postdoctoral Scientist,Computational epigenomics and Genetics Postdoctoral Scientist, Computational epigenomics and Genetics The Institute The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.The CRG is composed...
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Barcelona, España Centre For Genomic Regulation A tiempo completoYou are here:Home > Postdoctoral Scientist,Computational epigenomics and GeneticsPostdoctoral Scientist, Computational Epigenomics and GeneticsThe InstituteThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.The CRG is composed of...
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Barcelona, España Centre For Genomic Regulation A tiempo completoYou are here:Home > Postdoctoral Scientist, Computational epigenomics and GeneticsPostdoctoral Scientist, Computational epigenomics and GeneticsThe Institute The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.The CRG is composed of...
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Barcelona, España Centre for Genomic Regulation A tiempo completoYou are here: Home > Postdoctoral Scientist, Computational epigenomics and Genetics Postdoctoral Scientist, Computational Epigenomics and Genetics The Institute The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is...
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Barcelona, España Somma A tiempo completo.The InstituteThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.The CRG is composed of an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end...
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Barcelona, España Centre for Genomic Regulation A tiempo completoYou are here: Home > Postdoctoral Scientist, Computational epigenomics and Genetics Postdoctoral Scientist, Computational epigenomics and Genetics The Institute The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is...
-
Barcelona, España Somma A tiempo completo.The Institute The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.The CRG is composed of an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by...
-
Barcelona, España Barcelona Institute Of Science And Technology (Bist) A tiempo completo.The Institute The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.The CRG is composed of an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by...
-
Barcelona, España Barcelona Institute Of Science And Technology (Bist) A tiempo completoThe InstituteThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.The CRG is composed of an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end...
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Barcelona, España Center For Genomic Regulation A tiempo completo.The Institute The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.The CRG is composed of an interdisciplinary, motivated and creative scientific team supported by flexible and efficient administration and high-end innovative...
-
Barcelona, España Center for Genomic Regulation A tiempo completoThe Institute The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by...
-
Barcelona, España Barcelona Institute Of Science And Technology (Bist) A tiempo completo.The InstituteThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.The CRG is composed of an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end...
-
Barcelona, España Somma A tiempo completoThe Institute The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.The CRG is composed of an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end...
-
Barcelona, España Somma A tiempo completoThe InstituteThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.The CRG is composed of an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end...
-
Barcelona, España Barcelona Institute of Science and Technology (BIST) A tiempo completoThe Institute The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by...
-
Barcelona, España Barcelona Institute Of Science And Technology (Bist) A tiempo completo.The InstituteThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.The CRG is composed of an interdisciplinary, motivated, and creative scientific team supported by flexible and efficient administration and high-end innovative...
-
Barcelona, España Barcelona Institute Of Science And Technology (Bist) A tiempo completo.The Institute The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.The CRG is composed of an interdisciplinary, motivated, and creative scientific team supported by flexible and efficient administration and high-end innovative...
-
Barcelona, Barcelona, España Barcelona Institute Of Science And Technology (Bist) A tiempo completoThe Barcelona Institute of Science and Technology (BIST) is a leading international biomedical research institute, based in Barcelona, Spain. Our interdisciplinary team consists of over 400 scientists from 44 countries.We are committed to developing an HR Strategy for Researchers that aligns with the principles of the European Charter for Researchers and the...
-
Barcelona, España Barcelona Institute Of Science And Technology (Bist) A tiempo completoThe Institute The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.The CRG is composed of an interdisciplinary, motivated, and creative scientific team supported by flexible and efficient administration and high-end innovative...
-
Barcelona, España Barcelona Institute of Science and Technology (BIST) A tiempo completoThe Institute The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated, and creative scientific team supported by flexible and efficient administration and high-end innovative...
