Postdoctoral Scientist, Computational Epigenomics and Genetics
hace 2 semanas
The Institute
The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.
In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).
Please, check out our Recruitment Policy
The role
We are seeking a motivated postdoctoral scientist to lead a project in one of these two areas:
- Analysis and discovery of rare noncoding mutations causing diabetes, using advanced statistical genetics, computational regulatory genomics, and analysis of whole genome sequences in unique patient cohorts.
- Using computational strategies to develop a high resolution epigenomic technology with translational potential.
About the lab
The Regulatory Genomics and Diabetes lab aims to uncover genetic mechanisms causing diabetes mellitus, and to develop therapeutic avenues. The group is particularly interested in understanding how genomic information is used to direct cell-specific gene expression, and to pinpoint gene regulatory defects underlying human disease.
The team brings together diverse expertise, ranging from work with mutant stem cell-derived beta cell organoids, engineered mouse models, single cell epigenomics, large-scale genetic screens, statistical genetics, and the integration of genetic and regulatory data. This multidisciplinary approach gives us unique opportunities to engage in collaborative projects that combine experimental and computational methods. For a computational project, for example, this enables generating new datasets, and experimental testing of in silico predictions. The group is funded by European Research Council, the Spanish Ministry of Science and Innovation, Generalitat de Catalunya, an AXA chair, European Foundation for the Study of Diabetes, the Marie Skłodowska-Curie Actions program, a CIBERDEM diabetes network, and a collaborative project with biotech. The lab forms part of international consortia focused on advancing research in regulatory genomics, single cell genomics, and human genetics.
Recent studies from the lab include:
- A lineage-specific gene transcription and splicing hierarchy that is disrupted in type 2 diabetes.
(In review).
- Large-scale discovery of molecular targets for precision treatment of HNF1A-deficient diabetes.
(In review).
- Transcription regulation by long non-coding RNAs and its disease relevance (Nat Rev Mol Cell Biol, 2024).
- HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A (Nat Cell Biol 2022).
- Pancreas agenesis mutations disrupt a lead enhancer controlling a developmental enhancer cluster.(Dev Cell, 2022).
- Human pancreatic islet 3D chromatin architecture provides insights into the genetics of type 2 diabetes (Nat Genet 2019).
Whom would we like to hire?
Professional experience
Must Have
- You hold a PhD (or equivalent experience) in statistical genetics, genome or epigenome data analysis, or related fields
- You have proven programming competence in Python, R, or C++, or related languages, and expertise in Linux and high-performance computing environments
- Experience in genome sequence variant data and/or statistical genetics is highly advantageous to engage in a human variant analysis project. Experience in NGS data analysis is necessary to engage in an epigenomics technology project
Desirable but not required/ Nice to have
- A first-author publication track-record is highly advantageous
- A proven research track record in any other area of genome or epigenome data analysis is highly advantageous
Education and training
- You hold a PhD (or equivalent experience) in statistical genetics, genome or epigenome data analysis, or related fields
Languages
- You are fluent in English
Competences
- You desire and have the ability to work both collaboratively and independently within a multidisciplinary environment
The Offer - Working Conditions
- Contract duration: Contract for Technical and Scientific Activities - estimated duration of 2 years, with the possibility of renewal.
- Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.
- Target start date: January 2025
We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website
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Barcelona, España Centre For Genomic Regulation A tiempo completo.You are here:Home > Postdoctoral Scientist,Computational epigenomics and Genetics Postdoctoral Scientist, Computational Epigenomics and Genetics The InstituteThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.The CRG is composed...
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Barcelona, España Centre For Genomic Regulation A tiempo completo.You are here:Home > Postdoctoral Scientist,Computational epigenomics and GeneticsPostdoctoral Scientist, Computational Epigenomics and GeneticsThe InstituteThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.The CRG is composed of...
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Barcelona, España Center For Genomic Regulation A tiempo completo.The InstituteThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.The CRG is composed of an interdisciplinary, motivated and creative scientific team supported by flexible and efficient administration and high-end innovative...
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