Enzyme Optimization Expert

hace 1 semana


Barcelona, Barcelona, España Somma A tiempo completo

The Centre for Genomic Regulation (CRG) is a leading biomedical research institute based in Barcelona, Spain. Our team of over 400 scientists from 44 countries works together to advance the field of genomics and its applications. The CRG has been recognized for its commitment to developing an HR Strategy for Researchers, aligned with the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers.

About the Role

We are seeking an experienced Enzyme Optimization Specialist to lead the experimental testing and optimization of enzymes generated by our AI models. This role involves high-throughput screening and directed evolution approaches to efficiently manage and evaluate thousands of enzymes. The successful candidate will work closely with our AI-driven protein design team to validate predictions and improve models over time.

About the Lab

Our interdisciplinary research group is at the forefront of AI-driven protein design and engineering. We integrate computational scientists, experimental biologists, and biotechnologists to push the boundaries of synthetic biology and protein engineering. As an Enzyme Optimization Expert, you will be part of a collaborative and dynamic team that values innovation and creativity.

Requirements
  • 3+ years of experience in protein engineering, specifically in enzyme variant testing
  • Wide experience in implementing and screening enzyme activity assays
  • Familiarity with directed evolution techniques and (ultra)-high throughput techniques
  • Fluency in English and strong communication skills
Desirable Skills
  • Experience with robotic liquid-handling platforms for high-throughput workflows and automation
  • Ability to learn machine learning methods for protein engineering and design
Educational Background

You hold or are about to defend a PhD in Biochemistry, Chemistry, Molecular Biology, Biotechnology, or a related field.

Language Skills

You are proficient in English.

Technical Skills

Advanced skills in protein engineering techniques, such as mutagenesis, cell-free systems, and/or (ultra-) high-throughput assays. Ability to independently develop protocols to screen the activity, selectivity, and thermodynamics of enzyme variants.

Estimated Salary: €60,000 - €80,000 per annum, depending on experience.



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