Bioinformatician In The Group 'Evolutionary Processes Modeling'

hace 3 días


Barcelona, Barcelona, España Center For Genomic Regulation A tiempo completo

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Spain, with over 400 scientists from 44 countries. Our interdisciplinary team is supported by a flexible and efficient administration and high-end technologies.

The CRG received the renewal of the 'HR Excellence in Research' Award from the European Commission, recognizing our commitment to developing an HR Strategy for Researchers.

We are looking for a bioinformatician to join the 'Evolutionary Processes Modeling' group, which uses computational analysis of sequencing data, population genetics predictions, and statistical modeling to answer questions about mutational processes and selective pressures in cancer tumors.

Cancer is a genetic disease, subject to population genetics forces like mutation, selection, and stochasticity. Our group is particularly interested in how the evolution and survival of cancer cell populations relies on mutation influx as well as in selection inference from observed mutation data.

To this end, we develop mathematical and computational approaches to estimate mutation rates and selection. Coding sequences of cancer tumors exhibit positively selected mutations that drive cancer, and there also exists a small fraction of genes that the tumor cannot afford to lose.

We are also interested in mutation rates and selection inference in the context of human genetic variation, including polymorphisms and de novo variants. A particular focus of the group lies on the description of purifying selection in humans and across species, accounting for mutational processes as well as the effects of genetic drift.

The Evolutionary Processes Modeling lab was established in 2018 and is part of the 'Bioinformatics and Genomics' program at the CRG.



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    About the Centre for Genomic RegulationThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with over 400 scientists from 44 countries. Our interdisciplinary team is supported by a flexible and efficient administration and high-end innovative technologies.Job DescriptionWe are...


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