Research Scientist

hace 4 días


Barcelona, Barcelona, España Centre For Genomic Regulation A tiempo completo

**About the Centre for Genomic Regulation (CRG)**

The CRG is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. Our centre is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.

We are looking for a research scientist to join the "Evolutionary Processes Modeling" group. We use computational analysis of sequencing data together with population genetics predictions and statistical modeling to answer questions about mutational processes and selective pressures in cancer cells and in the human population. The ideal candidate should be highly motivated and eager to work on evolutionary and biological problems through the use and development of computational and statistical approaches.

About the Job

We offer a competitive salary of approximately €43,000 per year, depending on experience. As a research scientist at the CRG, you will have the opportunity to work on cutting-edge projects and collaborate with a talented team of researchers. You will analyze data, develop models for the description of tumor DNA sequencing data, develop a computational pipeline and test biological hypotheses.

About the Group

Cancer is a genetic disease, subject to population genetics forces like mutation, selection and stochasticity. Our group is particularly interested in how the evolution and survival of cancer cell populations relies on mutation influx and in how we can identify cancer driver events from observed mutation data. To this end, we develop mathematical and computational approaches to estimate mutation rates, tumor growth dynamics and selection. Analysis of the mutational processes acting in cancer genomes allows us to learn about carcinogenic mutagens, while studying the spatial genetic heterogeneity of tumors tells us about the tumor mode of growth. Estimates of the strength of selection in cancer allow a prioritization of genes and non-coding regions by their disease relevance, with the ultimate goal of promoting therapeutic advances.

Qualifications

  • You are familiar with the principles of evolutionary processes or population genetics.
  • You have experience with computer programming.
  • You have experience with modeling, statistical analysis and/or machine learning.
  • Experience with DNA- or RNA-sequencing data analysis is a plus.

About the Contract

We offer a technical and scientific activities contract estimated 1 year, to be extended up to a maximum of 3 years. The contract duration may vary depending on performance and the needs of the project.


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