Postdoctoral Researcher Position in Cancer Immuno-Biology
hace 2 semanas
About the Job
We are seeking a highly motivated and talented postdoctoral researcher to join our team at the Josep Carreras Leukaemia Research Institute (IJC). The successful candidate will work under the supervision of Dr. Manel Esteller in the Cancer Epigenetics Group.
Job Description
- Conduct experiments to identify mechanisms of response to HDAC6 inhibitors in cancer cells.
- Develop and implement novel combinatorial strategies to increase the efficacy of HDAC6 inhibitors in combination with bispecific antibodies and chimeric antigen receptor (CAR) T cells.
- Perform genome-wide CRISPR screening to identify new mechanisms of response to HDAC6 inhibitors.
- Analyze and interpret data from experiments, including single cell RNA-seq, spatial transcriptomics, and methylome arrays.
- Supervise students enrolled in the project and contribute to the development of research protocols.
Requirements
- PhD in Biomedical Sciences or a related field.
- Excellent track record of publications related to cancer immunotherapy and identification of mechanisms of response in preclinical in vitro and in vivo human models.
- Experience in cancer immunotherapy preclinical models, in vitro and in vivo, particularly bispecific antibodies and chimeric antigen receptors (CAR) T cells.
- Experience in the identification and validation of mechanisms of response to cancer therapies.
- Experience in translational research and animal work.
- Good communication skills in English and ability to work independently.
- Experience in supervising students.
- Motivation to achieve high-quality results.
What We Offer
- 3-year contract with the possibility of extension.
- Opportunity to contribute to cutting-edge research projects in Molecular Biology and Deep Learning approaches.
- Working in a mixed basic and clinical research environment at the IJC.
- Stimulating environment of the Barcelona metropolitan area.
- Full-time contract with competitive salary.
- Possibility of collaboration with international research groups.
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