Senior Biotechnology Research Scientist for Glycosidase Engineering

hace 1 semana


Barcelona, Barcelona, España Iqs A tiempo completo
Job Description

In this challenging role, you will join our team at IQS as a highly skilled Senior Biotechnology Research Scientist to lead the project: New-to-nature glycosidases as bio-orthogonal tools in metabolic labeling and microbiome studies. Your primary focus will be on protein engineering of carbohydrate active enzymes in biocatalysis and synthetic biology.

About the Project

The postdoctoral researcher will be mainly involved in and lead the collaborative project between the Planas Lab at IQS-URL, Barcelona (enzyme engineering and chemical biology) and the Peczuh's Lab at the University of Connecticut, USA (synthetic carbohydrate chemistry). The aim is to develop engineered glycosidase enzymes/un-natural glycoconjugate substrates pairs for the bio-orthogonal and selective in vivo unmasking of probes/metabolites/labeling agents by the genetically-encoded engineered hydrolase for metabolic labeling and microbiome studies.

Key Responsibilities
  • Design and implementation of diverse bio-orthogonal engineered glycosidase/un-natural glycoconjugate substrate pairs.
  • State-of-the-art protein design and engineering using directed evolution approaches.
  • Development of high-throughput screening methods.
  • Biochemical characterization of engineered variants for specificity and bio-orthogonality on designer unnatural glycoside conjugates.
Requirements

We are seeking a highly talented researcher with a PhD in Biotechnology, Biochemistry, or a related field. As a member of our team, you will have the opportunity to work with cutting-edge technologies and collaborate with renowned experts in the field.

Salary and Benefits

This two-year contract offers a competitive salary range of $60,000-$80,000 per annum, commensurate with experience, along with a comprehensive benefits package including health insurance, retirement plan, and paid time off.



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