Lab Technician for The Icaria Project

hace 3 semanas

Barcelona, España CREAL A tiempo completo

**Descripción**: The Barcelona Institute for Global Health (ISGlobal) is a cutting-edge institute addressing global public health challenges through research, translation into policy and education. ISGlobal has a broad portfolio in communicable and non-communicable diseases including environmental and climate determinants, and applies a multidisciplinary scientific approach ranging from the molecular to the population level. Research is organized in three main areas, Malaria and other Infectious Diseases, Child and Maternal Health, and Urban Health, Climate & Non-Communicable Diseases. ISGlobal is accredited with the Severo Ochoa distinction, a seal of excellence of the Spanish Science Ministry.
**Lugar**:

- Barcelona**What We Are Looking for**:
ISGlobal is seeking a full-time LAB TECHNICIAN who is interested in taking over and managing activities of the project “**Improving Child Health through Azithromycin Research for Infants in Africa** (ICARIA)”**

The overall project goal is to develop a precision medicine solution for the diagnosis of sepsis.

The** ICARIA** project, c**arried out in Sierra Leone, is a large-scale clinical trial which will measure the incremental mortality benefit of administering IPTi plus azithromycin to infants** with the goal of contributing to a reduction in child mortality in areas of high malaria and mortality burden in sub-Saharan Africa. ICARIA is a five-year project funded by the Bill & Melinda Gates Foundation and co-funded by La Caixa Foundation is coordinated by ISGlobal. The project evaluates the impact of azithromycin (AZi) plus IPTi with sulphadoxine-pyrimethamine (IPTi-SP) administered through the EPI in Sierra Leone on childhood mortality. The potential development of **antibiotic resistance**, the interactions with routine EPI immunisations, the safety and the impact on the health system of AZi and IPTi-SP administration will be all assessed in this trial.

A potential adverse consequence of the use of AZi could be the increase in carriage of AZi resistant organisms, especially Streptococcus pneumoniae. To assess the effect on gut bacterial composition and resistance, rectal samples will be collected from a randomly selected subsample of study children at recruitment and four weeks after the last dose of AZi/placebo. Following their collection, nasopharyngeal and rectal samples will be placed in cryotubes containing appropriate media and stored at -20ºC/-80ºC until tested. Bacterial colonies will be cultured and identified using non-selective and selective media with antibiotics. Pneumococcal identification will be based on colony morphology and conventional characterization methods. Samples will be collected in Sierra Leone and shipped by ISGlobal to the Subgrantee’s laboratory where the bacterial isolates will be evaluated for antimicrobial susceptibilities and the minimum inhibitory concentrations of the different antibiotics will be determined using the Clinical Breakpoint Tables from EUCAST (The European Committee on Antimicrobial Susceptibility Testing).

The activities in which the LAB TECHNICIAN Will be involved related to the Project Will be:

- Receive nasopharyngeal / rectal samples from the ICARIA project in Sierra Leone
- Analyse and characterize the pathogens in the samples and its antimicrobial susceptibility.

The tasks will be developed in the Microbiology Department at Hospital Clínic de Barcelona and at the research laboratory of Dr. Jordi Vila’s group at Centre Esther Koplowitz (CEK).

**Key Responsibilities**:
**Specific Duties**:

- The duties will consist on ensure the correct bloodstream samples collection of the hospital as well as to isolate and characterize the antimicrobial susceptibility profile of the bacterial samples by molecular methods as well as with the new tool.**Training and experience /Qualifications**:
Previous laboratory experience in the microbiology field. Experience in antimicrobial resistance will be highly appreciated.

**Specific Requirements**:
**Skills**:

- Teamwork.
- Problem resolution.
- Learning capacity.
- Previous experience in molecular microbiology

**Conditions**:

- Duration: March 2023- February 2024
- Starting date: 1st March 2023
- Contract: full time (8h / day)
- Salary Range: Technician 2C

**Selection Process**:
The selection process is designed in two phases:
1- Interview phase of a technical nature, with the team that requires the incorporation. To assess the person's skills and CV.

2 - Meeting with HR with the finalist(s) to finish assessing the profile and discuss contractual and institutional issues.

If needed any technical test could be pass. A Psychological Competency Evaluation Test will be required for the structural or transversal positions.

**How to apply**:
**Applications will be accepted until 17.00 CET of the closing date.**

In ISGlobal we are committed to maintaining and developing a work environment in which the values and principles of our organization are respected

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