Predoctoral Fpi Contract research Group On

hace 4 meses

Barcelona, España Vall d'Hebron Institut de Recerca A tiempo completo

VHIR-RRHH-FOR-003_vs02_

TheVall d'Hebron Research Institute

(VHIR) is a public sector institution that

promotes and develops the research,

innovation and biosanitary teaching of the

Vall d’Hebron University Hospital. Through

the excellence of our research, we identify

problems of society and we contribute to

spread them around the world.

In April 2015, the **Vall d’Hebron**

**Research Institute (VHIR) **obtained

the recognition of the European

Commission **HR Excellence.**

This recognition proves that VHIR

endorses the general principles of the

European Charter for Researchers and

a Code of Conduct for the Recruitment

of Researchers **(Charter & Code)**.

**VHIR embraces Equality and**

**Diversity. As reflected in our values**

**we work toward ensuring inclusion**

**and equal opportunity in**

**recruitment, hiring, training, and**

**management for all staff within the**

**organization, regardless of gender,**

**civil status, family status, sexual**

**orientation, gender identity and**

**expression, religion, age, functional**

**diversity or ethnicity.**

**Predoctoral FPI contract**

**Research group on Neuromuscular and Mitochondrial diseases**

VHIR offers a position for a Predoctoral researcher within the Research group on Neuromuscular and
Mitochondrial diseases to participate in the project “**_Identification of factors regulating mitochondrial _**
**_respiratory complex I function and stability: exploring novel opportunities for therapeutic intervention _**
**_(TARGETCOMPLEX-I)”. _**
- This contract is part of the project _**_PID2023-147668OB-I00_**_, financed by MCIN/AEI/10.13039/501100011033 _
- and by the FSE+”, by the Call Formación de Personal Investigador Predoctoral (FPI) linked to a Proyecto de _
- Generación del Conocimiento 2023. (see the call website here) _
- This project is intended to increase our knowledge on the mechanisms regulating respiratory complex I (CI) _
- function. Mutations affecting CI activity are not only the most frequent cause of mitochondrial disease, a subset _
- of rare diseases, but CI deficiency plays a pivotal role in many other prevalent diseases. _
- A few years ago, we described how a particular subunit of CI, NDUFA10, is bound to most of the dGTP present _
- 03568-6). This observation leads to our hypothesis that NDUFA10 may play additional roles within CI beyond _
- its participation in the holoenzyme stabilization. _
- Our first aim with this project is to gain understanding on NDUFA10 function within mitochondrial respiratory _
- complex I (CI). To this end, we plan a series of biochemical tests on different available models and the _
- generation of a new NDUFA10 mutant mouse with disrupted dGTP binding that allows to specifically address _
- the in vivo role of this interaction. _
- In addition, we will use an already available CI deficient mouse model with mutations in NDUFA10 (Ndufa10CI) _
- to explore the contribution of stress-elicited responses to disease and to tackle the study of mechanisms _
- involved in tissue-specific regulation of CI function and organization by a series of proteomic analyses. _
- VHIR-RRHH-FOR-003_vs02_

TheVall d'Hebron Research Institute

(VHIR) is a public sector institution that

promotes and develops the research,

innovation and biosanitary teaching of the

Vall d’Hebron University Hospital. Through

the excellence of our research, we identify

problems of society and we contribute to

spread them around the world.

In April 2015, the **Vall d’Hebron**

**Research Institute (VHIR) **obtained

the recognition of the European

Commission **HR Excellence.**

This recognition proves that VHIR

endorses the general principles of the

European Charter for Researchers and

a Code of Conduct for the Recruitment

of Researchers **(Charter & Code)**.

**VHIR embraces Equality and**

**Diversity. As reflected in our values**

**we work toward ensuring inclusion**

**and equal opportunity in**

**recruitment, hiring, training, and**

**management for all staff within the**

**organization, regardless of gender,**

**civil status, family status, sexual**

**orientation, gender identity and**

**expression, religion, age, functional**

**diversity or ethnicity.**
- Finally, we will use the Ndufa10CI mouse for the preclinical evaluation of different therapeutic strategies for _
- treating CI deficiency. _
- The FPI awardee will join our team to work developing some aspects of the mentioned project as part of his/her _
- PhD thesis. Our group is currently composed by 12 scientists at different stages of their career, 5 of them also _
- pursuing their PhD projects. We all share a strong scientific motivation and build and enriching, collaborative _
- and enjoyable work atmosphere. _

**JOB DESCRIPTION**

**Education and qualifications**:
**Required**:

- Bachelor’s ( 300 ECTS credits) or Master’s Degree in biomedical sciences (or equivalent)
- Fluency in English (written and spoken).

**Desi

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