Pre-doctoral Researcher

hace 2 semanas

Barcelona, España Vall d'Hebron Institut de Recerca A tiempo completo

VHIR-RRHH-FOR-003_vs01_

The Vall d'Hebron Research Institute

(VHIR) is a public sector institution that

promotes and develops the research,

innovation and biosanitary teaching of the

Vall d’Hebron University Hospital. Through

the excellence of our research, we identify

problems of society and we contribute to

spread them around the world.

In April 2015, the **Vall d’Hebron**

**Research Institute (VHIR) **obtained

the recognition of the European

Commission in **HR Excellence.**

This recognition proves that VHIR

endorses the general principles of the

European Charter for Researchers and

a Code of Conduct for the Recruitment

of Researchers **(Charter & Code)**.

**VHIR embraces Equality and**

**Diversity. As reflected in our values**

**we work toward ensuring inclusion**

**and equal opportunity in**

**recruitment, hiring, training, and**

**management for all staff within the**

**organization, regardless of gender,**

**civil status, family status, sexual**

**orientation, nationality, religion,**

**age, disability or race.**

**Pre-doctoral Researcher**

**Cardiovascular Diseases Research Group**

Cardiovascular Diseases. More information about our group can be found at:
**JOB DESCRIPTION**

**Education and qualifications:
**Required**:

- Degree in Biology, Biomedicine, Pharmacy, Biomedicine, Veterinary Medicine or a related discipline.
**- **Master degree.**:

- **High academic marks (degree and master) is a must.**:

- **Good communication skills and fluency in spoken and written English
**.**
**Desired**:

- Strong sense of responsibility, initiative, self-motivation and social skills as key personal abilities.
**- **Ability to work independently.**:

- **Previous publications.**:

- **Research stages abroad.**:

- **Accredited for animal handling.

**Experience and knowledge:
- Good knowledge in cell biology and physiology, aging oriented studies
**- **Previous experience in research using imaging techniques (confocal microscopy, TEM, real-time ionic
kinetics using fluorescent markers, histopathology, etc).**:

- **Interest and initiative in functional approaches using intact cells and organelles (mitochondria).
- Background in general biochemical techniques (Western blot, PCR, immunolabeling, etc).**
- VHIR-RRHH-FOR-003_vs01_

The Vall d'Hebron Research Institute

(VHIR) is a public sector institution that

promotes and develops the research,

innovation and biosanitary teaching of the

Vall d’Hebron University Hospital. Through

the excellence of our research, we identify

problems of society and we contribute to

spread them around the world.

In April 2015, the **Vall d’Hebron**

**Research Institute (VHIR) **obtained

the recognition of the European

Commission in **HR Excellence.**

This recognition proves that VHIR

endorses the general principles of the

European Charter for Researchers and

a Code of Conduct for the Recruitment

of Researchers **(Charter & Code)**.

**VHIR embraces Equality and**

**Diversity. As reflected in our values**

**we work toward ensuring inclusion**

**and equal opportunity in**

**recruitment, hiring, training, and**

**management for all staff within the**

**organization, regardless of gender,**

**civil status, family status, sexual**

**orientation, nationality, religion,**

**age, disability or race.
**Labour conditions**:

- **Position**: Full-time pre-doctoral position (40h/week).
- **Contract length**: 3 years (according to the conditions established by the grant holder (AGAUR/VHIR)).
- **Gross annual salary**: According to the conditions established by the grant holder.
- **Project title**: “Mitochondrial damage secondary to dicarbonyl stress as a driver of senescence: role of

senolytics in the protection of the aged heart” (project funded by the Instituto de Salud Carlos III, Ministerio
de Ciencia, Innovación y Universidades).**:

- Project Summary**:
During aging, the heart displays a lower tolerance to exercise and stress, the severity of which determines
the onset of heart failure (HF), a leading cause of death and disability worlwide. Reduced mitochondrial
respiratory function is a common mechanism underlying cardiac energy deficiency during both aging and
HF. Our group has identified dicarbonyl stress (the accumulation of toxic metabolic intermediates due to a
deficient detoxification system) as a prominent cause of mitochondrial dysfunction in the aged heart.
Dicarbonyl damage to target proteins cannot be removed therapeutically and tend to accumulate within
cells. In the present project, we hypothesize that mitochondrial dysfunction secondary to the accumulation
of dicarbonyl-induced damage triggers the development of cardiomyocyte senescence, a pathologic
phenotypic transformation characterized by profound metabolic and secretome changes that has
deleterious consequences on neighboring cells by paracrine mechanisms. We propose the use of senolytic
drugs as an innovative therapy to protect the aging heart against

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