Postdoctoral Fellow for The Colorectal Cancer Lab

hace 2 días

Barcelona, España Somm Excellence Alliance A tiempo completo

This international consortium has developed cutting-edge microscopy tools that contribute to the understanding of how cancer cells behave in complex 3D structures and enable robust interrogation of responses to cancer therapy with single cell resolution. Screens will include longitudinal live cell imaging assays and use sophisticated phenotypic endpoints - with the potential to link to and inform subsequent single cell genomic and proteomic analysis.

This project is financed by CRUK-AECC (GEACC19006BAT; from the Accelerator Awards of the "Fundación de la Asociación Española contra el Cancer (FAECC)").

KEY PUBLICATIONS RELATED TO THE PROJECT:
Cañellas-Socias, et al and Batlle E. Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells. Nature. Nov;611(7936):603-613. 2022.

Alvarez-Varela, et al. and Batlle E. Mex3a marks drug-tolerant persister colorectal cancer cells that mediate relapse after chemotherapy. Nature Cancer. Sep;3(9):1052-1070. 2022.

Herpes et al. and Batlle E, Throsby M. Functional screening on patient-derived organoids identifies a therapeutic bispecific antibody that triggers EGFR degradation in LGR5+ tumor cells. Nature Cancer. 3: 418-436. 2022.

Morral et al. and Batlle E. Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer. Cell Stem Cell. 26: 845-861. 2020

Cortina C, et al. and Batlle E. A genome editing approach to study cancer stem cells in human tumors. EMBO Molecular Medicine. 9 (7): 869-879. 2017

Tosi S, Bardia L, Filgueira MJ, Calon A and Colombelli J. LOBSTER: An environment to design bioimage analysis workflows for large and complex fluorescence microscopy data. Bioinformatics. 36(8):2634-2635. 2020

DUTIES:
Conduct independent research in the area of advanced microscopy applied to research with organoids, including novel spinning-disk and lightsheet-based high-throughput instruments.

Standardize advanced microscopy workflows for organoids screening across four European facilities.

Develop and/or use complex bioimage analysis assays for single cell analysis in high-content live large 3D image datasets.

EXPERIENCE, KNOWLEDGE, SKILLS:
Applications are invited from highly motivated and ambitious researchers with a PhD degree.

The applicant is expected to have experience in the area of microscopy.

Applicants should have excellent interpersonal and communication skills, organizational skills to plan experimental bench-work and the ability to work both as part of the team as well as independently.

**Deadline**: March 1, 2024
**Job category**: Postdoc
**Area**: Life Sciences

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