Postdoctoral Fellow for The Colorectal Cancer Lab

hace 2 semanas

Barcelona, España IRB Barcelona A tiempo completo

Created in 2005 by the Generalitat de Catalunya (Government of Catalonia) and the University of Barcelona, IRB Barcelona is a Severo Ochoa Centre of Excellence—a seal that was awarded in 2011.

The institute is devoted to conducting research of excellence in biomedicine and to transferring results to clinical practice, thus improving people’s quality of life, while simultaneously promoting the training of outstanding researchers, technology transfer, and public communication of science. Its 29 laboratories and seven core facilities address basic questions in biology and are orientated to diseases such as cancer, metastasis, Alzheimer’s, diabetes, and rare conditions.

IRB Barcelona is an international centre that hosts 500 members and 45 nationalities. It is located in the Barcelona Science Park. IRB Barcelona forms part of the Barcelona Institute of Science and Technology (BIST) and the “Xarxa de Centres de Recerca de Catalunya” (CERCA).

This international consortium has developed cutting-edge microscopy tools that contribute to the understanding of how cancer cells behave in complex 3D structures and enable robust interrogation of responses to cancer therapy with single cell resolution. Screens will include longitudinal live cell imaging assays and use sophisticated phenotypic endpoints - with the potential to link to and inform subsequent single cell genomic and proteomic analysis.

This project is financed by CRUK-AECC (GEACC19006BAT; from the Accelerator Awards of the "Fundación de la Asociación Española contra el Cancer (FAECC)").

**KEY PUBLICATIONS RELATED TO THE PROJECT**:
Cañellas-Socias, et al and **Batlle E**. _Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells._ **Nature**. Nov;611(7936):603-613. 2022.

Alvarez-Varela, et al. and **Batlle E**. _Mex3a marks drug-tolerant persister colorectal cancer cells that mediate relapse after chemotherapy_. **Nature Cancer**. Sep;3(9):1052-1070. 2022.

Herpes et al. and **Batlle E**, Throsby M. _Functional screening on patient-derived organoids identifies a therapeutic bispecific antibody that triggers EGFR degradation in LGR5+ tumor cells_. **Nature Cancer.** 3: 418-436. 2022.

Morral et al. and **Batlle E**. _Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer. _**Cell Stem Cell**. 26: 845-861. 2020

Cortina C, et al. and **Batlle E**_. A genome editing approach to study cancer stem cells in human tumors._ **EMBO Molecular Medicine**. 9 (7): 869-879. 2017

Tosi S, Bardia L, Filgueira MJ, Calon A and **Colombelli** **J**. _LOBSTER: An environment to design bioimage analysis workflows for large and complex fluorescence microscopy_ _data_. **Bioinformatics.** 36(8):2634-2635. 2020

**DUTIES**:

- Conduct independent research in the area of advanced microscopy applied to research with organoids, including novel spinning-disk and lightsheet-based high-throughput instruments.
- Standardize advanced microscopy workflows for organoids screening across four European facilities.
- Develop and/or use complex bioimage analysis assays for single cell analysis in high-content live large 3D image datasets.

**EXPERIENCE, KNOWLEDGE, SKILLS**:

- Applications are invited from highly motivated and ambitious researchers with a PhD degree.
- The applicant is expected to have experience in the area of microscopy.
- Applicants should have excellent interpersonal and communication skills, organizational skills to plan experimental bench-work and the ability to work both as part of the team as well as independently.

**WORKING CONDITIONS & ENTITLEMENTS**:

- **Working conditions**: Employed in compliance with Spanish legislation and regulations under a full-time contract. Employees receive the benefits of the Spanish Social Security system covering sickness, maternity/paternity leaves and injuries at work.
- **Training and Career**:Postdoctoral researchers joining IRB Barcelona gain access to the Institute’s advanced research training and career development opportunities, all within in a competitive international environment. Courses and workshops on themes of particular interest to postdocs are offered regularly by the Institute.
- **Estimated annual gross salary**: Salary commensurate with experience and qualifications.
- **International environment**:Nearly 90 Postdoctoral researchers (more than a half non-Spanish nationals) are currently working at IRB Barcelona.

**HOW TO APPLY & SELECTION PROCESS**:
Applications for the above opening should include **motivation letter, their CV and the name and addresses of three references**.
- **Number of positions available**: 1
- **Selection process**:

- **Pre-selection**: Will be based on CV, motivation letter & experience.

  • Postdoctoral Fellow for The Trip Clinics Laboratory

    hace 1 mes

    Barcelona, España IRB Barcelona A tiempo completo

    Created in 2005 by the Generalitat de Catalunya (Government of Catalonia) and the University of Barcelona, IRB Barcelona is a Severo Ochoa Centre of Excellence—a seal that was awarded in 2011. The institute is devoted to conducting research of excellence in biomedicine and to transferring results to clinical practice, thus improving people’s quality of...

  • Postdoctoral Associate in The Valcárcel Lab

    hace 4 semanas

    Barcelona, España Center for Genomic Regulation A tiempo completo

    **The Institute** The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by...

  • Lab Manager For The Stem Cell And Cancer

    hace 7 días

    Barcelona, España Somma A tiempo completo

    We are looking for a highly motivated Lab Manager with experience to support the Stem Cells and Cancer Laboratory. The Stem Cell and Cancer group headed by Salvador Aznar Benitah aims at understanding the molecular mechanisms underlying the spatiotemporal regulation of adult stem cells in the healthy tissue, and how these are deregulated during ageing and...

  • Post-doc Fellow

    hace 1 mes

    Barcelona provincia, España Springer Nature A tiempo completo

    **Post-doc Fellow - Bioinformatician / or Molecular Cancer Researcher**: - Employer- FUNDACIÓ DE RECERCA CLÍNIC BARCELONA-INST. D'INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER- Location- Barcelona (Provincia), Cataluña (ES)- Salary- Gross salary: around 55,000€/year, depending on experience and qualifications.- Closing date- 20 Apr 2024- Discipline ...

  • Postdoctoral Fellow at The Epigenetic Face of

    hace 4 semanas

    Barcelona, España Center for Genomic Regulation A tiempo completo

    **The Institute** The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by...

  • Postdoctoral Fellow

    hace 4 semanas

    Barcelona, España IRB Barcelona A tiempo completo

    Created in 2005 by the Generalitat de Catalunya (Government of Catalonia) and the University of Barcelona, IRB Barcelona is a Severo Ochoa Centre of Excellence—a seal that was awarded in 2011. The institute is devoted to conducting research of excellence in biomedicine and to transferring results to clinical practice, thus improving people’s quality of...

  • Ref. 2024-014-01 Bioinformatician for The Cancer

    hace 1 mes

    Barcelona, España Somm Excellence Alliance A tiempo completo

    The Vall d´Hebron Institute of Oncology (VHIO) Seeks a “Bioinformatician for the Cancer Genomics Lab” Reference: Ref. 2024-014-01 Application deadline: until position filled. Number of vacancies: 1 Job description: We are seeking a bioinformatician to join the Cancer Genomics Lab at VHIO. The scope of the work will be mostly linked to the analysis...

  • Postdoctoral Fellow

    hace 4 semanas

    Barcelona, España Somm Excellence Alliance A tiempo completo

    We are seeking a Postdoctoral Computational Biologist/Bioinformatician for a collaborative project between the “Targeted Protein Degradation & Drug Discovery lab” (IRB Barcelona) and the spin-off “Nostrum Biodiscovery” (NBD) focused on molecular modeling and drug discovery. NBD is a young spin-off of the Barcelona Supercomputing Center, the...

  • Postdoctoral Fellow at The Epigenetic Face of

    hace 4 semanas

    Barcelona, España Somm Excellence Alliance A tiempo completo

    The Institute The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by...

  • Places de Postdoctoral Research Fellow in

    hace 4 semanas

    Barcelona, España Universitat de Barcelona (UB) A tiempo completo

    Universitat de Barcelona (UB). 2 places de Postdoctoral Research Fellow in Philosophy - TAMP. Concurs o valoració de mèrits. Laboral temporal. 2024-02-29. Termini obert. A1 - Grau universitari (correspondència amb llicenciatures). Títol de doctorat en Filosofia Veure convocatòria - Contracte laboral indiferent - Jornada indiferent

  • Postdoctoral Fellow Pathogenic Yeast Genomics and

    hace 4 semanas

    Barcelona, España Somm Excellence Alliance A tiempo completo

    IRB Barcelona is seeking an experimental Postdoctoral Researcher in pathogenic yeast genomics and evolution. DUTIES: - Plan, perform and interpret experiments in the framework of the project - Contribute to other lab projects and to the maintenance of protocols and laboratory resources in the group. - Critically analyze analytical results, participate in...

  • Postdoctoral Researcher

    hace 1 mes

    Barcelona, España Center for Genomic Regulation A tiempo completo

    **The Institute** The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by...

  • Plaça de Lab Manager at The Epigenetic Face of

    hace 7 días

    Barcelona, España Centre de Regulació Genòmica (CRG) A tiempo completo

    Centre de Regulació Genòmica (CRG). 1 plaça de Lab Manager at the Epigenetic Face of Cancer Metabolism Group. Concurs o valoració de mèrits. Laboral temporal. 2024-02-29. Termini obert. A1 - Grau universitari (correspondència amb llicenciatures). Màster en biologia o similar. Anglès expert Veure convocatòria - Contracte laboral indiferent - Jornada...

  • Ref. 2024-026-01 Lab Manager at The Tumor

    hace 4 semanas

    Barcelona, España Somm Excellence Alliance A tiempo completo

    The Vall d´Hebron Institute of Oncology (VHIO) Seeks a “Lab Manager at the Tumor Immunology & Immunotherapy Group” Reference: 2024-026-01 Application deadline: until position filled. Number of vacancies: 1 Job description: Application: About VHIO: Under the leadership of Josep Tabernero, the Vall d’Hebron Institute of Oncology (VHIO), has...

  • Postdoctoral Fellow

    hace 4 semanas

    Barcelona, España European Molecular Biology Laboratory A tiempo completo

    Postdoctoral Fellowships - Barcelona, Spain he European Molecular Biology Laboratory (EMBL) is one of the highest ranked scientific research organizations in the world. The newest EMBL site is located in the Barcelona Biomedical Research Park (PRBB), one of the largest infrastructures in Southern Europe dedicated to translational research. The main focus...

  • Plaça de Lab Technician in Cancer Researc Cido

    hace 4 semanas

    Barcelona, España Institut de Recerca Biomèdica (IRB) A tiempo completo

    Institut de Recerca Biomèdica (IRB). 1 plaça de Lab Technician in Cancer Researc. Laboral temporal. 2023-08-25. Termini obert. A1 - Grau universitari (correspondència amb llicenciatures). Llicenciatura en biologia, bioquímica o àrees afins. Fluïdesa en anglès Veure convocatòria - Contracte laboral indiferent - Jornada indiferent

  • Lab manager

    hace 3 días

    Barcelona, España Rejuversen A tiempo completo

    Job Position at RejuversenResearch technician/lab manager –Barcelona-basedTo apply please send a cover letter and your CV to Marc Armengol marc.antoni@rejuversentx.comRejuversen is a start-up biotechnology company that develops therapies to eliminate senescent cells in a spectrum of diseases. The company was founded in 2020 and has a lead program in...

  • Postdoc Position in The ‘cell and Tissue

    hace 1 mes

    Barcelona, España Center for Genomic Regulation A tiempo completo

    **The Institute** The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by...

  • Lab manager

    hace 3 días

    Barcelona, Barcelona, España Rejuversen A tiempo completo

    Job Position at RejuversenResearch technician/lab manager –Barcelona-basedTo apply please send a cover letter and your CV to Marc Armengol Rejuversen is a start-up biotechnology company that develops therapies to eliminate senescent cells in a spectrum of diseases. The company was founded in 2020 and has a lead program in oncology and early target...

  • Postdoctoral Researcher ‘advanced Fluorescence

    hace 4 semanas

    Barcelona, España Center for Genomic Regulation A tiempo completo

    **The Institute** The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by...