Postdoc Position In Rna Splicing

hace 4 semanas


Barcelona, España Center For Genomic Regulation A tiempo completo

.The InstituteThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated and creative scientific team supported by a flexible and efficient administration and by high-end and innovative technologies.In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).The roleAlternative splicing (AS) is the important process that allows the production of different messenger RNAs and proteins from a single gene in humans and other complex organisms. AS plays a crucial role in mechanisms controlling gene expression. Mutations affecting AS contribute to the development of many diseases, including cancer. While drugs that target AS have recently entered the clinic and provided the first therapy for common genetic disorders, there is still much to be learnt about the mechanisms controlling splicing and their modulation by small molecules. Small molecule inhibitors of spliceosome assembly have been used to generate alterations in RNA processing in cancer cells leading to the synthesis of neoantigens. The role of the postdoc to be hired will be to contribute to the characterization of molecular mechanisms of AS regulation by small molecule modulators of RNA splicing, the generation of neoantigens and their characterization for their potential use in immunotherapy. This is a collaborative project (CANCERNA) supported by the EC-funded H2020 Health Program.About the teamThe group of Juan Valcárcel at the Center for Genomic Regulation (CRG) of Barcelona has a long trajectory studying pre-mRNA splicing regulation. The group combines high-throughput methods with detailed biochemical and cellular assays and collaborates closely with other groups working on computational and structural biology to study molecular mechanisms and networks of alternative splicing regulation in cancer. The group also develops mechanism-based novel therapeutic approaches for oncology



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    **The Institute** The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by...


  • Barcelona, España Centre For Genomic Regulation A tiempo completo

    The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated, and creative scientific team supported by a flexible and efficient administration and high-end and innovative...


  • Barcelona, España Centre For Genomic Regulation A tiempo completo

    The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.The CRG is composed of an interdisciplinary, motivated, and creative scientific team supported by a flexible and efficient administration and high-end and innovative...


  • Barcelona, España Centre For Genomic Regulation A tiempo completo

    The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated, and creative scientific team supported by a flexible and efficient administration and high-end and innovative...


  • Barcelona, España Centre For Genomic Regulation A tiempo completo

    The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.The CRG is composed of an interdisciplinary, motivated, and creative scientific team supported by a flexible and efficient administration and high-end and innovative...


  • Barcelona, España Center For Genomic Regulation A tiempo completo

    The Institute The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end...


  • Barcelona, España Center For Genomic Regulation A tiempo completo

    The Institute The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.The CRG is composed of an interdisciplinary, motivated, and creative scientific team which is supported by a flexible and efficient administration and by high-end and...


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    The InstituteThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated, and creative scientific team which is supported by a flexible and efficient administration and by high-end and...


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    .The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated, and creative scientific team supported by a flexible and efficient administration and high-end and innovative...


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  • Barcelona, España Center For Genomic Regulation A tiempo completo

    The Institute The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.The CRG is composed of an interdisciplinary, motivated and creative scientific team supported by a flexible and efficient administration and by high-end and...


  • Barcelona, España Centre For Genomic Regulation A tiempo completo

    The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated, and creative scientific team supported by a flexible and efficient administration and high-end and innovative...


  • Barcelona, España Center For Genomic Regulation A tiempo completo

    The InstituteThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated and creative scientific team supported by a flexible and efficient administration and by high-end and...


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    Job Title: Postdoctoral Researcher in RNA Splicing and Gene RegulationJob Summary: We are seeking a highly motivated postdoctoral researcher to join our team at Nccr RNA & Disease, focusing on the characterization of molecular mechanisms of alternative splicing (AS) regulation.Key Responsibilities:Contribute to the UNLEASH project, funded by the European...


  • Barcelona, Barcelona, España Nccr Rna & Disease A tiempo completo

    Job Title: Postdoctoral Researcher in RNA Splicing and Gene RegulationJob Summary: We are seeking a highly motivated postdoctoral researcher to join our team at Nccr RNA & Disease, focusing on the characterization of molecular mechanisms of alternative splicing (AS) regulation.Key Responsibilities:Contribute to the UNLEASH project, funded by the European...


  • Barcelona, Barcelona, España Center for Genomic Regulation A tiempo completo

    About the RoleThe Center for Genomic Regulation (CRG) is seeking a highly motivated Postdoctoral Researcher to join our team in the field of RNA Splicing Regulation. As a key member of our team, you will contribute to the characterization of molecular mechanisms of alternative splicing regulation by small molecule modulators of RNA splicing.About the TeamThe...