Postdoc Position in Rna Splicing

hace 4 meses

Barcelona, España Center for Genomic Regulation A tiempo completo

**The Institute**

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.

In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).

Please, check out our Recruitment Policy

**The role**

Alternative splicing (AS) is the important process that allows the production of different messenger RNAs and proteins from a single gene in humans and other complex organisms. AS plays a crucial role in mechanisms controlling gene expression. Mutations affecting AS contribute to the development of many diseases, including cancer. While drugs that target AS have recently entered the clinic and provided the first therapy for common genetic disorders, there is still much to be learnt about the mechanisms controlling splicing and their modulation by small molecules. Small molecule inhibitors of spliceosome assembly have been used to generate alterations in RNA processing in cancer cells leading to the synthesis of neoantigens. The role of the postdoc to be hired will be to contribute to the characterization of molecular mechanisms of AS regulation by small molecule modulators of RNA splicing, the generation of neoantigens and their characterization for their potential use in immunotherapy. This is a collaborative project (CANCERNA) supported by the EC-funded H2020 Health Program.

**About the team**

The group of Juan Valcárcel at the Center for Genomic Regulation (CRG) of Barcelona has a long trajectory studying pre-mRNA splicing regulation. The group combines high-throughput methods with detailed biochemical and cellular assays and collaborates closely with other groups working on computational and structural biology to study molecular mechanisms and networks of alternative splicing regulation in cancer. The group also develops mechanism-based novel therapeutic approaches for oncology. Juan Valcárcel obtained his PhD from work on influenza virus splicing regulation carried out in the lab of Juan Ortín at the Center of Molecular Biology Severo Ochoa in Madrid. After a postdoc with Michael Green at the University of Massachusetts, working on mechanisms of splice site recognition and regulation, he established his group at the European Molecular Biology Laboratory (EMBL) in Heidelberg in 1996. In 2002 the group moved to the newly created Center for Genomic Regulation (CRG) of Barcelona. He is a Research Professor of the Catalonian Institute for Research and Advanced Studies (ICREA) and associated Professor of the University Pompeu Fabra. Elected EMBO member in 2004, he was Deputy Coordinator of the European Alternative Splicing Network of Excellence and Coordinator of the RNAREG Consolider consortium, the European Innovation Council-funded TAONas-LUAD and the Eurpean Research Council-funded UNLEASH projects. He is member of the Editorial Board of the Journals Molecular Cell, RNA and Molecular and Cellular Biology as well as of the Scientific Advisory Boards of several Research Institutes and companies in Europe and USA. He served as President of the RNA Society in 2017-2018 and as Past-President in 2019-2020. Our team is currently composed of 2 technicians, 1 lab manager, 2 PhD students, 5 postdocs and 1 Staff Scientist.

**Whom** would we like to hire?**

**Professional experience**

**Must Have**
- You have a PhD in Molecular Biology
- You have proven experience in Molecular Biology and Gene Regulation

**Desirable but not required/ Nice to have**
- Computational Biology Skills
- Experience with RNA analysis
- Experience with RNA and Disease

**Education and training**
- You hold a PhD in Molecular Biology

**Languages**
- You are proficient in English

**Technical skills**
- Highly developed organizational skills
- Independence
- Professional ambition
- Capacity for team work

**Competences**
- Highly developed organizational skills
- Independence
- Professional ambition
- Capacity for teamwork

**The Offer** - Working Conditions**
- **Contract d**uration**: technical and scientific activities contract linked to the project (estimated until 31/05/2025 with the possibility to extend to 16 months)
- **Estimated annual gross salary**: Salary is commensurate with qualifications and consistent with our pay scales
- **Target s**tart date**: September 2024

We provide a highly stimulating environment with state-of-the-art infrastructure

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