Postdoc – Gene Regulation In Hematopoiesis
hace 3 semanas
The Institute
The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated, and creative scientific team supported by flexible and efficient administration and high-end innovative technologies.
In April 2021, the CRG received the renewal of the 'HR Excellence in Research' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to align practices and procedures with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers.
The role
The Single Cell and Synthetic Genomics of Blood Formation lab (PI: Lars Velten) at CRG Barcelona is looking for a motivated computational or mixed computational-experimental postdoc to use synthetic enhancers, CRISPR screening, and computational approaches to unravel the logic of gene regulation in blood stem cell differentiation.
In your new role, you would:
Develop a project on gene regulation in the blood forming system.
Analyze data from synthetic enhancer MPRA screens, single cell MPRA screens, and dual MPRA-CRISPR screens.
Design experiments using these technologies and collaborate with an experienced technician to implement these experiments.
Interact closely with both wetlab and computational scientists from the group.
Serve as a senior member of the team and, down the road, co-supervisor of PhD students or technical staff.
Your work would be part of the project "Artificial Intelligence for Synthetic Genomics of Blood," funded with a prestigious ERC Starting Grant.
About the lab
My interdisciplinary group investigates the biology of hematopoietic stem cells using a combination of single cell genomics, genetic screens, and computational biology. We strive to develop novel genomic and bioinformatic tools to answer longstanding questions in the field.
Whom would we like to hire?
Professional experience
Must Have:
You hold a PhD in a relevant field (computational biology, genomics, molecular biology, bioinformatics, biotechnology, etc.).
You have demonstrated your ability to lead a challenging research project.
You have published at least one primary research paper during your PhD.
You have strong experience in the analysis of non-standard genomics data (e.g., Perturb-Seq, CRISPR screens, Nanopore, custom RNA-seq protocols, etc.).
You have strong programming skills in R or Python.
You embrace data-driven research and are willing to collaborate with computational biologists.
Desirable but not required:
You have training in experimental work (e.g., cell culture, flow cytometry, cloning, library preparation, etc.).
A strong foundation in machine learning and statistics.
You have experience with deep learning environments such as TensorFlow and PyTorch.
Education and training
A PhD in a relevant field (biochemistry, biomedicine, molecular biology, genetics, etc.).
Languages
You are proficient in English.
Technical skills
Genomics data analysis, R, and Python.
Competences
Success-driven.
Strong academic writing skills.
Strong communication skills.
Ability to work as part of a team.
The Offer – Working Conditions
Contract duration: technical and scientific activities contract, estimated 2 years.
Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.
Target start date: January 2025 (flexible).
Application Procedure
All applications must include:
A motivation letter addressed to Dr. Lars Velten.
A complete CV including contact details.
Contact details of two referees.
Deadline: Please submit your application by October 17, 2024.
The contract will be financed by the ERC Starting Grant AI4SYN.
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