2025_144_research assistant_genetics

JOB DESCRIPTION

Our group is a multidisciplinary team that carries out both translational and clinical research as we are members of the Genetics Department and the Clinical Pharmacogenomics group. In particular, we, the Clinical Genomics Research group focuses on the development of new tools for genetic diagnosis and also on building the foundations of a personalized strategy for Neurofibromatosis and Schwannomatosis. We are also discovering new prognostic biomarkers, understanding the role of genomic alterations in the development of disease-associated lesions, and implementing various gene therapy strategies to cure these diseases. Furthermore, we participate on the Spanish Reference Center (CSUR) for patients with Phakomatoses (Neurofibromatoses, Schwannomatosis, Tuberous Sclerosis, and Von-Hippel Lindau diseases), which is a part of the European Network of Reference Centers (ERN) GENTURIS. Currently we are also the coordinators of international Variant Curation Expert Panel (VCEP) for Neurofibromatoses and Schwannomatosis by ClinGen (NIH) to stablish the variant classification ACMG rules for the genes causing these diseases. We are currently participating in a national project to determine the clinical utility of analyzing different polymorphisms to reduce side effects and improve adherence to certain drugs (pharmacogenomics) from mass genotyping (IPHARMDX (IMPACT pharmacogenomics)) within the clinical pharmacogenomics working group. Our lines of research are: 1) development of new methodologies to improve current genomic testing; 2) massive genotyping to establish the personalized risk of specific diseases (Polygenic Risk Score) or adverse reactions to certain drugs (pharmacogenomics); among others. In addition, we are also coordinating the European project EJPRD_NF to improve the genetic testing and variant classification for Neurofibromatosis type 1 and Schwannomatosis by applying new genomic technologies and also by the use of iPSC-derived cell models. We are looking for an organized and motivated research assistant who is team-oriented and has previous experience with molecular biology (e.g., PCRs, sequencing, Western blots), genetics, and cell cultures. The ideal candidate will have a desire to work in a multidisciplinary team focused on clinical genetics and translational research. The main project in which the candidate would participate is in pharmacogenomics and PRS, although participation in the group's other projects is expected. If the candidate is interested, the possibility of pursuing a Ph.D. could be evaluated.

QUALIFICATIONS AND EXPERIENCIEDegree in biology, biochemistry, genetics or similar, with human genetics knowledge. Applicants with degrees in other life sciences will be considered providing they can demonstrate expertise in human genetics. Experience in cell culture and molecular biology techniques (primary cell cultures or iPSC cultures will be positively evaluated)Knowledge of genetics and different genotyping and NGS techniques will be an advantFluent English.Good interpersonal and organizational skills.Attention to detail.Candidates must be highly motivated, tidy, responsible and proactive, with the ability to work in a dynamic team environmentWHAT WE OFFERType of contract and working hours: Full time. Indefinite contract (Indefinido por actividades científico-técnicas ley de la ciencia (17/2022) linked to the project  IPHARMDX and EJPRD, with the possibility of seeking further funding to undertake a PhD or continuing as research assistance on the group's various projects.Date of incorporation: January 2026Gross annual remuneration inherent to the square objected to this call, will be fixed based on the experience provided and the skills of the candidate, distributed in 12 payments.Flexible payment (childminding vouchers).23 days holiday and 5 days for personal matters + 2 personal days for Easter + 2 personal days for Christmas. Training capsules by the company.Be part of an excellent multidisciplinary research centre with the HRS4R badge.Location on the Can Ruti Campus, a first-class translational research environment in the Barcelona area, in a very stimulating scientific environment. The IGTP offers a supportive, friendly and collaborative ecosystem to promote professional development and help you achieve your research goals.HOW TO APPLY

Interested persons must attach to the application:

Motivation letter explaining their interest in the position.Updated CV.Contact of 2-3 references.Applications will be evaluated in accordance with the guiding principles and objectives of the supply systems, following the process described below:Curricular evaluation: analysis of the curriculum vitae to assess aspects related to training, professional career and experience in positions related to the job position under selection.Personal interview: once the résumé has been evaluated, the selected candidates will be called for a personal interview to verify and expand on the information detailed in the résumé and to evaluate aspects related to experience and professional skills.Applications that do not meet the requirements, that are not included in the cases foreseen or that are not processed in accordance with the established procedure will not be considered in the selection process.MAIN RESPONSIBILITIESAs a member of the Clinical Pharmacogenomics Unit, you will participate in the various ongoing projects in the laboratory, research activities and publications, but primarily in carrying out the different high-throughput genotyping projects and other cellular and molecular biology techniques.You will actively assist in and implement new protocols to improve the genomic diagnostic techniques available in the laboratory, participate in research activities within the clinical genomics group, and contribute to team research publications.You will work daily as part of a multidisciplinary team with clinical staff, bioinformaticians, biologists and molecular geneticists.You will interact with experts in medicine, pharmacy, genetics and bioinformatics to jointly evaluate different project designs, protocols, results obtained, etc., participating in regular group meetings to understand clinical and research needs and to improve the required experiments.If the candidate is interested, the possibility of pursuing a Ph.D. could be evaluated.FOR MORE INFORMATION

 
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DEADLINE FOR APPLICATIONS

The call for applications will close on November, 30th

RESOLUCION

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