Vac 32 2025 - Postdoctoral Researcher (Endothelial..

The Josep Carreras Leukaemia Research Institute (IJC) is a comprehensive **cancer research center** dedicated to conduct research and drive innovation in the epidemiological, preventive, clinical, translational, and basic aspects of leukaemia and other hematologic malignancies, with the final aim of finding a cure for these diseases. It was created in 2010, and since then has experienced an exponential growth.

The IJC is also part of the network of Excellence Research Centers of Catalonia **(CERCA)** and was accredited as a **Severo Ochoa Center of Excellence** by the Ministry of Science, Innovation, and Universities in 2024. Since 2018, the Institute has also been accredited by the Scientific Foundation of the Spanish Association Against Cancer **(FCAECC)** Additionally, IJC is one of the centers integrated into the Institut de Recerca Germans Trias i Pujol (IGTP) accreditation as Accredited Health Research Institute (IIS) by the Carlos III Health Institute **(ISCIII)**.

The IJC's main headquarters is located within the Can Ruti Biomedical Campus, alongside other leading biomedical institutions, providing direct access to cutting-edge scientific and technological facilities, as well as complementary community services. The IJC has **six locations integrated into reference hospitals**: Hospital Germans Trias i Pujol, Hospital Clínic, Hospital Sant Pau, Hospital Josep Trueta, Hospital del Mar and Hospital San Joan de Déu. This facilitates close collaboration between basic and clinical researchers, fostering translational research that integrates basic science with clinical practice in clinical settings.

We are looking for a **POSTDOCTORAL RESEARCH**to be part of the Graupera lab. Project funded by the PTEN Foundation “Mapping the mechanisms of lesion onset and progression in PHtS-related vascular malformations (MAPten)”.

**RESEARCH DESCRIPTION**

Our research is devoted to study the biology of the endothelium and its role in disease towards the development of therapeutic strategies to target this compartment. Specifically, we aim to untackel the fundamental insights of vessel growth and function in developmental setting as well as to identify the pathological contexts in which the vasculature plays a critical role either intrinsically, as in vascular anomalies, or extrinsically as in cancer.

**MAIN RESPONSABILITIES**
- Experimental design of the project.
- Working with complex genetically engineered mouse models including monitoring of the colony.
- Isolation and culture of primary endothelial cells.
- Work with mouse models of vascular malformations
- scRNAseq data, processing and analysing
- Supervision of master and PhD students.
- Prepare formal reports for oral and written presentations.
- Data integration and interpretation.

**WHAT WE NEED**
- PhD in the biomedicine or similar
- Background in disease models.
- Expertise in epifluorescence and confocal microscopy.
- Expertise in signalling
- Expertise in scRNAseq
- Experience in working with mice as experimental model system.
- Experience in advanced molecular biology techniques (qPCR, etc).
- A high level of motivation and interest.
- Ability to handle varying workloads and aptitude for teamwork.
- High level of collaborative and communicative skills.
- Good level of English speaking and writing skills (required). Spanish (helpful).

**WHAT WE OFFER**
- Temporary position: 3 years (postdoctoral contract)
- An exciting and innovative research project.
- Working in the mixed basic and clinical research environment of the Josep Carreras Leukaemia Research Institute.
- Incorporation in a multinational and highly collaborative team.
- The stimulating environment of the Barcelona metropolitan area.

**DEADLINE**

**WHO WE ARE?**

**_ What makes us different?_**:
The mission of the Josep Carreras Institute is to conduct research and drive innovation in the epidemiological, preventive, clinical, translational, and basic aspects of leukaemia and other hematologic malignancies, with the final aim of finding a cure for these diseases.
The IJC’s vision is to be a world-class reference and excellent research multicampus that contributes to the improvement of results, and the cure of patients affected by leukemia and other malignant hemopathies, through innovation, sustainability, social responsibility, talent, and professional experience.

**_ HR Excellence_**:
In 2019, IJC was honored with the “Human Resources Excellence in Research Award” by the European Commission, recognizing the alignment of our human resources policies with the European Charter for Researchers and Code of Conduct for the Recruitment of Researchers. The Human Resources Strategy for Researchers (HRS4R) guides research centers of excellence in implementing and upholding these standards within their policies, emphasizing training, professional development, and mobility opportunities.
The IJC’s commitment to these values and principles strengthens our internal policies and ensures that our m