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hace 2 semanas
At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.
The Senior Scientist position is a scientific job with responsibility for pharmacometrics (PMx) activities including population PK, PKPD, exposure-response, and drug-disease modelling in all clinical development phases. With support from more senior Pharmacometricians, Team Leads and the TA Head, the incumbent will be responsible for integrating and analysing internal (and external) data to support interpretation and decision making.
**Responsibilities**:
- Accountable for data integration, analysis, and reporting of PMx results at the study level
- Accountable for executing state-of-the-art PMx techniques with direct value for the project
- Contribute PMx activities to influence study designs and go/no go decisions
- Contribute to regulatory documents and interactions (written)
- Presentation of PMx results in internal and external forum
- Contribute to internal initiatives to develop the pharmacometric discipline including its processes
- Participation in peer review of ongoing activities, reports and presentations
- Compliance with Good Clinical Practice (GCP) regulations as well as internal/external guidance’s
**Requirements**:
- Demonstrated experiences in pharmacometrics, including PK, PKPD and/or statistics
- Strong quantitative skills (e.g. experience in population modelling, statistics, systems and translational pharmacology modelling).
- Ability to identify, develop and execute clinical pharmacometrics activities at a project level
- Basic oral and written communication skills
- Fluency in English (oral and written)
- PhD degree preferred or equivalent (M.Sc./Pharm.D.) with relevant experience required
- Training and experience with pharmacometrics PK/PD software (NonMem, R, Stan, Monolix, or similar)
**Desirable**:
- Scientific publishing in the field on pharmacometrics
- Early or late phase clinical development experience/awareness
- Experience with concentration-QTc pharmacometrics analysis
