Vac 47 2025 - Predoctoral Researcher

The Josep Carreras Leukaemia Research Institute (IJC) is a comprehensive **cancer research center** dedicated to conduct research and drive innovation in the epidemiological, preventive, clinical, translational, and basic aspects of leukaemia and other hematologic malignancies, with the final aim of finding a cure for these diseases. It was created in 2010, and since then has experienced an exponential growth.

The IJC is also part of the network of Excellence Research Centers of Catalonia **(CERCA)** and was accredited as a **Severo Ochoa Center of Excellence** by the Ministry of Science, Innovation, and Universities in 2024. Since 2018, the Institute has also been accredited by the Scientific Foundation of the Spanish Association Against Cancer **(FCAECC)** Additionally, IJC is one of the centers integrated into the Institut de Recerca Germans Trias i Pujol (IGTP) accreditation as Accredited Health Research Institute (IIS) by the Carlos III Health Institute **(ISCIII)**.

The IJC's main headquarters is located within the Can Ruti Biomedical Campus, alongside other leading biomedical institutions, providing direct access to cutting-edge scientific and technological facilities, as well as complementary community services. The IJC has **six locations integrated into reference hospitals**: Hospital Germans Trias i Pujol, Hospital Clínic, Hospital Sant Pau, Hospital Josep Trueta, Hospital del Mar and Hospital San Joan de Déu. This facilitates close collaboration between basic and clinical researchers, fostering translational research that integrates basic science with clinical practice in clinical settings.

We are seeking **a Predoctoral Researcher**to provide scientific support to the Lymphocyte Development and Disease group led by Dr. Maribel Parra.

**RESEARCH DESCRIPTION**

The Lymphocyte Development and Disease group is devoted to understanding the transcriptional and epigenetics events underlying B cell development and their potential deregulation in leukemia and lymphoma. We work on the concept that gene transcriptional repression is critical for the acquisition of proper B cell identity.

The main research lines of our laboratory are:

- Investigating the role of the transcriptional repressor HDAC7 during B cell development
- Identifying novel epigenetic regulators essential for proper B cell generation
- Establishing HDAC7 as a novel biomarker and potential therapeutic target in pro-B acute lymphoblastic leukemia (pro-B-ALL) and Diffuse Large B Cell Lymphoma (DLBCL)
- Implementing 3D organoid cultures from DLBCL sample patients.

**MAIN RESPONSABILITIES**

**WHAT WE NEED**
- MSc in Genetics and Genomics.
- More han two years of experience in laboratory animal experimentation.
- Committed scientist with a competitive scientific record and experience in cellular and molecular biology, epigenetics, B cell biology and associated malignancies.
- A high level of motivation and interest in biomedical research.
- Good communication skills.
- Being open-minded, flexible and collaborative.
- Fluent in English.

**WHAT WE OFFER**
- Temporary Contract (3 months)
- Full time contract.
- Este contrato es parte de la ayuda RYC2021-031197-I, financiado por MCIN/AEI/10.13039/501100011033 y por la Unión Europea “NextGenerationEU”/PRTR
- The opportunity to contribute to cutting-edge translational research projects in the stimulating environment of the Josep Carreras Leukaemia Research Institute.
- The stimulating environment of the Barcelona metropolitan area.
- Opportunity for professional growth in an advanced research environment.

**DEADLINE**

**WHO WE ARE?**

**_ What makes us different?_**:
The mission of the Josep Carreras Institute is to conduct research and drive innovation in the epidemiological, preventive, clinical, translational, and basic aspects of leukaemia and other hematologic malignancies, with the final aim of finding a cure for these diseases.
The IJC’s vision is to be a world-class reference and excellent research multicampus that contributes to the improvement of results, and the cure of patients affected by leukemia and other malignant hemopathies, through innovation, sustainability, social responsibility, talent, and professional experience.

**_ HR Excellence_**:
In 2019, IJC was honored with the “Human Resources Excellence in Research Award” by the European Commission, recognizing the alignment of our human resources policies with the European Charter for Researchers and Code of Conduct for the Recruitment of Researchers. The Human Resources Strategy for Researchers (HRS4R) guides research centers of excellence in implementing and upholding these standards within their policies, emphasizing training, professional development, and mobility opportunities.
The IJC’s commitment to these values and principles strengthens our internal policies and ensures that our members have the optimal conditions and environment for their professional development.
The Board of Trustees is composed of representa