OPEN CALL FOR PREDOCTORAL FELLOWSHIP- FPU FI-AGAUR Joan Oró

hace 1 semana


Badalona, España IGTP A tiempo completo

The selected candidate will join the Grup de Recerca Neuromuscular de Badalona (GRENBA) an interdisciplinary team at the IGTP. GRENBA combines clinical experimental and computational approaches to advance research on rare neuromuscular diseases with a particular focus on myotonic dystrophy type 1 (DM1). The fellow will contribute to our research program analysing biological samples from DM1 patients enrolled in the DM1-Hub Spain national patient registry. At GRENBA we apply long‑read sequencing technologies to investigate the repetitive region associated with DM1 and we use bioinformatics and biostatistics to refine patient stratification and deepen understanding of disease. The candidate will design and implement innovative transcriptomic and metabolomic methodologies and multi‑omics integration approaches to uncover novel mechanisms underlying DM1 and related neuromuscular disorders.MAIN RESPONSIBILITIESStudy of patient samples through long‑read sequencing focusing on the characterization of the DMPK region (expansion variants, epigenetics and mosaicism). Integration of multi‑omics data including transcriptomic and metabolomic datasets to investigate disease mechanisms and identify potential biomarkers.Development of proteomic protocols through ELISA and Western blot for biomarker validation.Develop cell lines from patient samples for biomarker validation and preclinical drug testing.Maintain accurate experimental records and document results in a reproducible format.Collaboration with clinical and experimental teams to ensure translational relevance of the findings and contributions.Preparation of scientific publications, conference presentations and reports derived from the project outcome.QUALIFICATIONS AND EXPERIENCEEssential:MSc (or equivalent) in Genetics, Biotechnology, Biomedicine, Biochemistry, Biology, Health Sciences or closely related field.Minimum average grade of the undergraduate record equal to or greater than 8.5 (scale 0‑10).Competencies and skills: Communication, teamwork and collaboration, commitment, proactivity, integrity, critical and analytical thinking.High level of Spanish and English written and spoken. Catalan is a plus.Advantageous:Hands‑on experience with wet laboratory techniques: long‑read sequencing, NGS, PCR, genomics, proteomics and/or transcriptomics.Hands‑on experience in cell and tissue culture: aseptic techniques and sterile laboratory practices.Scientific writing and presentation skills as evidenced by peer‑reviewed publications and conference contributions.International experience.WHAT WE OFFERPre‑doctoral contract, full‑time (1628 h/year).Flexible



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