OPEN CALL FOR PREDOCTORAL FELLOWSHIP- FPU/ FI-AGAUR Joan Oró

hace 21 horas


badalona, España IMPPC, Institut de Medicina Predictiva i Personalitzada del Cancer A tiempo completo

Job Description The selected candidate will join the Grup de Recerca Neuromuscular de Badalona (GRENBA), an interdisciplinary team at the IGTP. GRENBA combines clinical, experimental, and computational approaches to advance research on rare neuromuscular diseases, with a particular focus on myotonic dystrophy type 1 (DM1). The fellow will contribute to our research program analyzing biological samples from DM1 patients enrolled in the DM1-Hub, Spain's national patient registry. At GRENBA, we apply long‑read sequencing technologies to investigate the repetitive region associated with DM1, and we use bioinformatics and biostatistics to refine patient stratification and deepen understanding of disease pathophysiology. In addition, the candidate will design and implement innovative transcriptomic and metabolomic methodologies and multi‑omics integration approaches to uncover novel mechanisms underlying DM1 and related neuromuscular disorders. Responsibilities Study patient samples through long‑read sequencing, focusing on characterization of the DMPK region (expansion, variants, epigenetics, mosaicism). Integrate multi‑omics data, including transcriptomic and metabolomic datasets, to investigate disease mechanisms and identify potential biomarkers. Develop proteomic protocols through ELISA and Western Blot for biomarker validation. Develop cell lines from patient samples for biomarker validation and preclinical drug testing. Maintain accurate experimental records and document results in a reproducible format. Collaborate with clinical and experimental teams to ensure translational relevance of the findings. Prepare scientific publications, conference presentations, and reports derived from the project outcome. Qualifications MSc (or equivalent) in Genetics, Biotechnology, Biomedicine, Biochemistry, Biology, Health Sciences, or closely related field. Minimum average grade of the undergraduate studies or equivalent degree equal to or greater than 8.5 (scale 0‑10). Competencies and skills: Communication, teamwork and collaboration, commitment, proactivity, integrity, critical and analytical thinking. High level of Spanish and English, written and spoken. Catalan is a plus. Additional qualifications (Advantageous) Hands‑on experience with wet laboratory techniques, long‑read sequencing, NGS, PCR, genomics, proteomics, and/or transcriptomics. Experience in cell and tissue culture, aseptic techniques and sterile laboratory practices. Scientific writing and presentation skills, as evidenced by peer‑reviewed publications and conference contributions. International experience. Benefits Pre‑doctoral contract with FPU‑2026, FI‑AGAUR‑2026 or similar grant. Full‑time contract (1628 h/year). Flexible



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