Cell Biology Specialist Position

hace 2 semanas


Barcelona, Barcelona, España Center For Genomic Regulation A tiempo completo

The Center for Genomic Regulation (CRG) is a leading international biomedical research institute based in Barcelona, Spain. As a vibrant and diverse community of over 400 scientists from more than 44 countries, we are dedicated to advancing our understanding of the molecular mechanisms underlying life processes. Our Institute is recognized for its commitment to developing an HR Strategy for Researchers, aligned with the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers.

The Role

We are seeking a Cell Biology Specialist to join our team in investigating the mechanism by which cells efficiently secrete bulky cargoes such as collagens, mucins, and chylomicrons. This involves collaborating with our team to analyze data that suggests the involvement of transient tunnels propelling these molecules from the endoplasmic reticulum lumen to the next compartment of the secretory pathway. The role will require expertise in in vitro and in vivo analyses, leveraging optogenetically controlled functions of TANGO1 and inhibitors to address the mechanism in both healthy and fibrotic tissues.

About the Lab

Our lab has a strong focus on addressing the mechanism of export of bulky cargoes from metazoan cells. We have identified key components such as TANGO1 and aim to visualize and characterize the route taken by these cargoes during their export from the ER. We also investigate how good collagens are selected while misfolded collagens and mucins are degraded, ultimately aiming to understand cell-controlled secretion of these molecules in the right quantity and quality. This research is essential for understanding tissue organization and addressing human pathologies linked to tissue fibrosis.

Required Skills and Qualifications
  • Comprehensive understanding of modern approaches in molecular cell biology, including genetic manipulation, super-resolution microscopy, and publications demonstrating expertise in respective procedures.
  • Proficiency in imaging techniques and experience with protein purification.
  • Desirable skills include expertise in working with animal models, bioinformatic tools (e.g., Python/R, omics data analysis), and advanced imaging techniques.
Benefits

As a Cell Biology Specialist at CRG, you will be part of a dynamic and collaborative environment with access to state-of-the-art infrastructures. Our generous compensation package includes an estimated annual gross salary: €54,000. Additional benefits include flexible working hours and an extended vacation period, enabling you to maintain a healthy work-life balance. We foster a diverse and inclusive environment, welcoming applicants from all backgrounds.



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