Scientific Researcher Position

hace 5 días


Barcelona, Barcelona, España Centre For Genomic Regulation A tiempo completo

Establish yourself in a dynamic environment at the Centre for Genomic Regulation (CRG), an international biomedical research institute of excellence based in Barcelona, Spain. We offer a unique opportunity to contribute to groundbreaking research and develop your career as a postdoctoral researcher.

The CRG is a hub for interdisciplinary scientific inquiry, comprising over 400 scientists from 44 countries. Our team is driven by a passion for discovery and a commitment to advancing our understanding of genomic regulation. We are currently seeking a highly motivated postdoctoral researcher to join our team and contribute to a project focused on understanding how cells secrete bulky cargoes like collagens, mucins, and chylomicrons.

We have identified transient tunnels that propel these bulk molecules from the endoplasmic reticulum lumen to the next compartment of the secretory pathway, thus bypassing the use of a vesicular intermediate. TANGO1 and its binding partners mediate this event. A number of new genes potentially involved in this biochemical reaction have been identified. This role will require a mix of in vitro and in vivo analyses. Optogenetically controlled function of TANGO1 and inhibitors are being used to address the mechanism both in healthy and fibrotic tissues.

About the Project: The project aims to visualize and characterize the route taken by the bulky cargoes for their export from the ER. We are addressing the issue of how good collagens are selected while the misfolded collagens and mucins are degraded, and work is in progress to express the entire collagen production and secretion system in yeast. By addressing these issues, we ultimately aim to understand how cells control the secretion of these molecules in the right quantity and of the right quality. This is essential for the organization of cells in a tissue and a means to address collagen and mucin hypersecretion linked to human pathologies of tissue fibrosis.



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