Postdoctoral Position in Pathogenicity Prediction
hace 6 meses
VHIR-RRHH-FOR-003_vs02_
TheVall d'Hebron Research Institute
(VHIR) is a public sector institution that
promotes and develops the research,
innovation and biosanitary teaching of the
Vall d’Hebron University Hospital. Through
the excellence of our research, we identify
problems of society and we contribute to
spread them around the world.
In April 2015, the **Vall d’Hebron**
**Research Institute (VHIR) **obtained
the recognition of the European
Commission **HR Excellence.**
This recognition proves that VHIR
endorses the general principles of the
European Charter for Researchers and
a Code of Conduct for the Recruitment
of Researchers **(Charter & Code)**.
**VHIR embraces Equality and**
**Diversity. As reflected in our values**
**we work toward ensuring inclusion**
**and equal opportunity in**
**recruitment, hiring, training, and**
**management for all staff within the**
**organization, regardless of gender,**
**civil status, family status, sexual**
**orientation, religion, age, disability**
**or race.**
**Postdoctoral Position in Pathogenicity Prediction**
**Models for Missense Mutations**
**Clinical and Translational Bioinformatics Group**
VHIR offers a vacant for a Postdoctoral position within the Clinical and Translational Bioinformatics**_. _**
**JOB DESCRIPTION**
**Education and qualifications**:
**Required: -**
PhD in Bioinformatics applied to Biomedicine
- M.Sc. in Bioinformatics applied to Biomedicine
- Fluency in Spanish and English
**Desired: -**
Additional training in Machine Learning and Data Analysis
- Knowledge of Catalan
**Experience and knowledge**:
**Required: -**
Experience in models for variant pathogenicity prediction: more than 3 years of proven experience building tools
for predicting the quantitative impact of missense variants on functional assays, particularly in cancer related
proteins like BRCA1 and BRCA2.
- Proficiency in developing Machine Learning tools for Supervised (regression/classification) and Unsupervised
(clustering, regularization) problems.
- VHIR-RRHH-FOR-003_vs02_
TheVall d'Hebron Research Institute
(VHIR) is a public sector institution that
promotes and develops the research,
innovation and biosanitary teaching of the
Vall d’Hebron University Hospital. Through
the excellence of our research, we identify
problems of society and we contribute to
spread them around the world.
In April 2015, the **Vall d’Hebron**
**Research Institute (VHIR) **obtained
the recognition of the European
Commission **HR Excellence.**
This recognition proves that VHIR
endorses the general principles of the
European Charter for Researchers and
a Code of Conduct for the Recruitment
of Researchers **(Charter & Code)**.
**VHIR embraces Equality and**
**Diversity. As reflected in our values**
**we work toward ensuring inclusion**
**and equal opportunity in**
**recruitment, hiring, training, and**
**management for all staff within the**
**organization, regardless of gender,**
**civil status, family status, sexual**
**orientation, religion, age, disability**
**or race. -**
Proficiency in Python and Python-related packages (scikit-learn, tensorflow, etc)
- Proven knowledge and experience with cost models for tool selection
- Good knowledge of bioinformatics tools, particularly for the representation of 3D structures and their analysis,
common bioinformatics databases (ClinVar, UniProt, PDB, etc.)
- Proven familiarity, at the data analysis level, with single-cell data and related bioinformatics tools
**Desired: -**
Familiarity with HTML5, CSS3, JavaScript, Git, and Bash.
- Experience working with AlphaFold models
**Main responsibilities and duties: -**
Responsible of carrying part of the central research activities of Objective 1 from project PID2022-142753OB
- I00. These include:
- Keep up-to-date our dataset of massive functional assays (survey literature for newly published DMS
experiments, critical analysis of the data, and normalization)
- Implement regularization analysis for regression models
- Survey routinely the literature for the best classification methods that can be combined with quantitative
methods
- Implement sequence and structure-only versions of our predictors
- Establish, if and when required, a cost-based evaluation pipeline of pathogenicity predictors
- Supervise the participation of our group in the coming editions of the CAGI challenge
- Contribute to the maintenance of the group's computer system
- Collaborate in the analysis of single-cell studies of Parkinson disease
- Contribute, when required, to the publications of the group on pathogenicity prediction
- VHIR-RRHH-FOR-003_vs02_
TheVall d'Hebron Research Institute
(VHIR) is a public sector institution that
promotes and develops the research,
innovation and biosanitary teaching of the
Vall d’Hebron University Hospital. Through
the excellence of our research, we identify
problems of society and we contribute to
spread them around the w
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