Technician - Study of Lymphoma Formation

hace 1 mes

Barcelona, España Centre for Genomic Regulation (CRG) A tiempo completo

**The Institute**

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.

**The role**

**About the lab**

Tumors originate from normal cells that acquire tumor-initiating genetic events, such as translocations and somatic mutations. These genetic hits turn normal cells into pre-malignant cells, but do not lead to immediate tumor formation. For that, secondary genetic events as well as epigenetic hits are required.

We are an expanding lab that recently was awarded an ERC starting grant providing funds for the coming 5 years. We aim to create a better understanding of how epigenetic tumor-associated changes arise in the context of non-Hodgkin lymphomas. To that end, we aim to study the occurrence of these changes in healthy individuals as well as in pre-malignant cells _in vitro_ (to be created by CRISPR/Cas9 genomic editing) and _in vivo_ using single-cell technologies. On top of that, we aim to define cell intrinsic mechanisms, such as enhancer activation and 3D chromatin interactions,that influence the occurrence of the observed changes.

**Whom would we like to hire?**

**Professional experience**

**Must Have**
- Minimum of 3 years of hands-on experience in biomedical/biology related experimental work.

**Desirable but not required/ Nice to have**

Hands-on expertise in:

- Epigenetic analyses (e.g. ChIP-seq, ATAC-seq, bisulfite sequencing, chromatin conformation capture).
- Culturing, in vitro differentiation and manipulation of primary cell types (preferably hematopoietic cells)
- Cell transfection protocols, including generation of the required plasmids
- Genome-editing strategies (preferably hematopoietic cells)
- Generation of next-generation sequencing libraries in different experimental contexts
- FACS sorting
- Valid accreditation and recent hands-on experience in working with laboratory animals, especially mice

**Education and training**

At least 3 years of hands-on experience in biomedical/biology related experimental work, combined with any of the following:

- A lab technician qualification
- A PhD degree in Biology (or related disciplines)
- A bachelor/master’s degree in Biology (or related disciplines)

**Languages**
- You are proficient in English

**Technical skills**
- Hands-on experience in at least 3 of the following areas:

- Basic molecular biology
- NGS methods
- CRISPR/Cas9-based technologies
- Mammalian cell culture, including transfection methods for (primary) cell systems
- FACS sorting
- Epigenetic analyses
- Optimisation of complex protocols
- Working with laboratory animals, especially mice

**Competences**
- Highly developed organization skills
- Excellent problem-solving skills
- Motivation to learn new techniques
- Enthusiasm and dedication to implement new protocols in the lab
- Good communication skills
- Capability to work on different projects simultaneously as part of a team and/or independently

**The Offer - Working Conditions**
- **Contract duration**:2 years with a possibility to extend
- **Estimated annual gross salary**:Salary is commensurate with qualifications and consistent with our pay scales
- **Target start date**:01/02/2023

We offer and **promote a diverse and inclusive environment** and welcomes applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity.

The **CRG is committed to reconcile a work and family life** of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.

**Application Procedure**
- A motivation letter addressed to R.Beekman.
- A complete CV including contact details.
- Contact details of two referees.

**Selection Process**

Application Deadline: 11/01/2023
Expected Start Date: 01/02/2023

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