Postdoctoral Researcher: From Active Matter to

hace 2 semanas

Barcelona, España Springer Nature A tiempo completo

**POSTDOCTORAL RESEARCHER: FROM ACTIVE MATTER TO INTRACELLULAR SELF-ORGANIZATION”**:

- Employer- CRG-Centre for Genomic Regulation- Location- Barcelona (Localidad), Cataluña (ES)- Salary- Salary is commensurate with qualifications and consistent with our pay scales- Closing date- 6 May 2024- Discipline
Biomedicine, Chemistry, Physics
Job Type
Postdoctoral
Employment - Hours
Full time
Duration
Fixed term
Qualification
PhD
Sector
Academia- You need to sign in or create an account to a job.

**The Institute**

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.

In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).

Please, check out our Recruitment Policy

**The role**

A postdoc position is available in the framework of the ERC Synergy project BIOMECANET which aims at understanding the design principles of mitotic spindle assembly and function using biochemical in vitro reconstitutions, computer simulations and cell biological studies. We are looking for a talented biochemist or biophysicist interested in pushing forward our attempts to reconstitute dynamic spindle-like structures from purified proteins. Our goal is to understand how active matter can form bipolar microtubule assemblies able to segregate chromosomes. Key techniques to be used will be protein biochemistry, quantitative fluorescence microscopy and microfabrication.

**About the lab**

The Intracellular Self-Organization lab lead by Thomas Surrey is interested in the question of biological self-organization. In particular, we aim to understand how the cytoskeleton of living cells organizes itself. The lab uses a bottom-up synthetic biology approach and has pioneered a number of novel microscopy-based in vitro reconstitutions that provide insight into the molecular mechanisms underlying microtubule cytoskeleton organization, dynamics and function. The lab is particularly interested in the question of how mitotic spindles assemble and reorganize during cell division, having a physics-inspired "active matter" perspective of the cytoskeleton.

Selected recent publications:
Brito, Serna, Guerra, Llorca, Surrey. Transition of human γ-tubulin ring complex into a closed conformation during microtubule nucleation. Science 383, 870-876 (2024).

Henkin, Brito, Thomas, Surrey. The minus-end depolymerase KIF2A drives flux-like treadmilling of γTuRC-uncapped microtubules. J Cell Biol 222, e202304020 (2023).

Henkin, Chew, Nédélec, Surrey. Cross-linker design determines microtubule network organization by opposing motors. PNAS 119, e2206398119 (2022).

Hannabuss, Ramirez, Cade, Fourniol, Nédélec, Surrey. Self-organization of mínimal anaphase spindle midzone bundles. Curr Biol 29, 2120-2130 (2019).

Roostalu, Rickman, Thomas, Nédélec, Surrey. Determinants of Polar versus Nematic Organization in Networks of Dynamic Microtubules and Mitotic Motors. Cell 175, 796-808 (2018).

**Whom would we like to hire?**

**Professional experience**

**Must Have**

You have extensive experience in protein biochemistry/biophysics

You have a strong interest in understanding molecular mechanisms

You have at least one first-author publication in a peer-reviewed journal

**Desirable but not required**

Experience in advanced optical microscopy

Experience in cytoskeleton/active matter research

Good programming skills

**Education and training**

You hold a PhD in biochemistry, biophysics or equivalent

**Languages**

You are fluent in English

**Technical skills**

Talent for experimental work

Excellent writing skills

**Competences**

Ability to grasp quantitative concepts

Highly developed organizational skills

**The Offer - Working Conditions**

**Contract duration**: 3 years

**Estimated annual gross salary**:Salary is commensurate with qualifications and consistent with our pay scales.

**Target start date**:summer/autumn 2024

We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section.

**We offer and promote a diverse and inclusive environment** and welcomes applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender

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